Human PDE6D Recombinant Protein – Cat# MBS1579384

PDE6D Human Recombinant Protein

Name: PDE6D Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1579384
Price: 575 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1579384

MBS1579384 is a recombinant protein targeting PDE6D. Also known as Recombinant Human PDE6D Protein, C-Fc. Host: Mammalian. More details

$575 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PDE6D, Recombinant Protein

Full Product Name

Recombinant Human PDE6D Protein, C-Fc

Product Gene Name

PDE6D recombinant protein

Product Synonym Names

PDE6D; Protein p17; GMP-PDE delta; Retinal rod rhodopsin-sensitive cGMP 3'; 5'-cyclic phosphodiesterase subunit delta; PDED

Host

Mammalian

Form/Format

Lyophilized from a solution in PBS pH7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Purity/Purification

>90% as determined by SDS-PAGE

Preparation and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 degree C for one week. Store at -20 degree C for twelve months from the date of receipt.

Molecular Weight

17,420 Da

Sequence Positions

Met1-Val150

OMIM

602676

3D Structure

ModBase 3D Structure for O43924

Species

Human

Reconstitution

Reconstitute in sterile water for a stock solution.

Product Categories/Family for PDE6D recombinant protein

Recombinant Proteins

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for PDE6D recombinant protein

SDS-PAGE (SDS), Western Blot (WB), ELISA (EIA), Immunogen

Other Notes

Small volumes of PDE6D recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE6D. It may not necessarily be applicable to this product.

NCBI GI #

597518021

NCBI GeneID

5147

NCBI Accession #

NP_001277947.1

UniProt Primary Accession #

O43924

UniProt Secondary Accession #

O43250

UniProt Related Accession #

O43924

GenBank Nucleotide #

NM_001291018.1

NCBI Official Full Name

retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform 2

NCBI Official Synonym Full Names

phosphodiesterase 6D, cGMP-specific, rod, delta

NCBI Official Symbol

PDE6D

NCBI Official Synonym Symbols

PDED; JBTS22

UniProt Protein Name

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

UniProt Synonym Protein Names

Protein p17

Protein Family

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase

UniProt Gene Name

PDE6D

UniProt Synonym Gene Names

PDED; GMP-PDE delta

UniProt Entry Name

PDE6D_HUMAN

NCBI Protein Information

retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; GMP-PDE delta; protein p17

NCBI Summary for PDE6D

This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants. [provided by RefSeq, Mar 2014]

UniProt Comments for PDE6D

PDE6D: Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation. Belongs to the PDE6D/unc-119 family.

Chromosomal Location of Human Ortholog: 2q35-q36

Cellular Component: cytoskeleton; cytoplasmic vesicle membrane; cytoplasmic vesicle; cytosol

Molecular Function: protein binding; 3',5'-cyclic-nucleotide phosphodiesterase activity; Rab GTPase binding; GTPase inhibitor activity

Biological Process: visual perception; metabolic process; organelle organization and biogenesis; negative regulation of catalytic activity; response to stimulus

Disease: Joubert Syndrome 22

Research Articles on PDE6D

1. Study identifies PDE6D as a novel Joubert syndrome gene and provides the first evidence of prenyl-binding-dependent trafficking in ciliopathies.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PDE6D recombinant protein

Reference Product	PubMed Publications
ARL2 recombinant protein	>5 publications with PDE6D and ARL2
GUCY2F recombinant protein	>1 publications with PDE6D and GUCY2F
ARL13B recombinant protein	>1 publications with PDE6D and ARL13B
RHEB recombinant protein	>1 publications with PDE6D and RHEB

Pathways associated with PDE6D recombinant protein

Products by Pathway	Pathway Diagram
ARL13B-mediated Ciliary Trafficking Of INPP5E Pathway antibodies	ARL13B-mediated Ciliary Trafficking Of INPP5E Pathway Diagram
Assembly Of The Primary Cilium Pathway antibodies	Assembly Of The Primary Cilium Pathway Diagram
Cargo Trafficking To The Periciliary Membrane Pathway antibodies	Cargo Trafficking To The Periciliary Membrane Pathway Diagram
Organelle Biogenesis And Maintenance Pathway antibodies	Organelle Biogenesis And Maintenance Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram

Diseases associated with PDE6D recombinant protein

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>4 publications with PDE6D and Disease Models, Animal
Atrophy Antibodies	>3 publications with PDE6D and Atrophy
Nervous System Diseases Antibodies	>1 publications with PDE6D and Nervous System Diseases
Kidney Diseases Antibodies	>1 publications with PDE6D and Kidney Diseases

Organs/Tissues associated with PDE6D recombinant protein

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>16 publications with PDE6D and Eye
Lung Antibodies	>2 publications with PDE6D and Lung
Kidney Antibodies	>2 publications with PDE6D and Kidney
Brain Antibodies	>2 publications with PDE6D and Brain
Spleen Antibodies	>1 publications with PDE6D and Spleen
Liver Antibodies	>1 publications with PDE6D and Liver