PDXP Recombinant Protein

Name: PDXP Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203739
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203739

Pyridoxal phosphate phosphatase, also known as PDXP is the enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. PDXP catalyzes the dephosphorylation of pyridoxal 5'-phosphate and exhibits a high level of… More details

$245 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PDXP, Recombinant Protein

Full Product Name

PDXP, 1-296aa, Human, His tag, E Coli

Product Gene Name

PDXP recombinant protein

Product Synonym Names

Pyridoxal phosphate phosphatase; CIN; PLP; PLPP; Pyridoxal phosphate phosphatase

Sequence

MGSSHHHHHH SSGLVPRGSH MARCERLRGA ALRDVLGRAQ GVLFDCDGVL WNGERAVPGA PELLERLARA GKAALFVSNN SRRARPELAL RFARLGFGGL RAEQLFSSAL CAARLLRQRL PGPPDAPGAV FVLGGEGLRA ELRAAGLRLA GDPSAGDGAA PRVRAVLVGY DEHFSFAKLR EACAHLRDPE CLLVATDRDP WHPLSDGSRT PGTGSLAAAV ETASGRQALV VGKPSPYMFE CITENFSIDP ARTLMVGDRL ETDILFGHRC GMTTVLTLTG VSRLEEAQAY LAAGQHDLVP HYYVESIADL TEGLED

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 0.1M NaCl

Purity/Purification

> 95% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

33.8 kDa (316aa) confirmed by MALDI-TOF

OMIM

AY125047 mRNA

3D Structure

ModBase 3D Structure for Q96GD0

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for PDXP recombinant protein

Metabolism

Applications Tested/Suitable for PDXP recombinant protein

SDS-PAGE

Product References and Citations for PDXP recombinant protein

Jang YM., et al. (1992) J Biol Chem. 278 (50):50040-6.; Fonda ML., et al. (1992) J Biol Chem. 267 (22):15978-83.;

Other Notes

Small volumes of PDXP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDXP purchase

MBS203739 is a recombinant protein targeting PDXP. Also known as PDXP, 1-296aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PDXP. It may not necessarily be applicable to this product.

NCBI GI #

10092677

NCBI GeneID

57026

NCBI Accession #

NP_064711

UniProt Primary Accession #

Q96GD0

UniProt Secondary Accession #

Q9UGY2

UniProt Related Accession #

Q96GD0

GenBank Nucleotide #

NM_020315.4

NCBI Official Full Name

pyridoxal phosphate phosphatase

NCBI Official Synonym Full Names

pyridoxal phosphatase

NCBI Official Symbol

PDXP

NCBI Official Synonym Symbols

CIN; PLP; dJ37E16.5

UniProt Protein Name

Pyridoxal phosphate phosphatase

UniProt Synonym Protein Names

Chronophin

Protein Family

Pyridoxal phosphate phosphatase

UniProt Gene Name

PDXP

UniProt Synonym Gene Names

CIN; PLP; PLPP; PLP phosphatase

NCBI Protein Information

pyridoxal phosphate phosphatase

NCBI Summary for PDXP

Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008]

UniProt Comments for PDXP

Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine (PubMed:15580268). Pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP (PubMed:14522954).

Research Articles on PDXP

1. Chronophin has a role in coordinating cell leading edge dynamics by controlling active cofilin levels

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PDXP recombinant protein

Reference Product	PubMed Publications
PDXK recombinant protein	>4 publications with PDXP and PDXK

Pathways associated with PDXP recombinant protein

Products by Pathway	Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Vitamin B6 Metabolism Pathway antibodies	Vitamin B6 Metabolism Pathway Diagram
Vitamin B6 Metabolism Pathway antibodies	Vitamin B6 Metabolism Pathway Diagram
Pyridoxal 5'-phosphate Salvage Pathway antibodies	Pyridoxal 5'-phosphate Salvage Pathway Diagram

Diseases associated with PDXP recombinant protein

Disease Name	Pubmed Publications
Lung Neoplasms Antibodies	>3 publications with PDXP and Lung Neoplasms
Nervous System Diseases Antibodies	>2 publications with PDXP and Nervous System Diseases
Inflammation Antibodies	>2 publications with PDXP and Inflammation

Organs/Tissues associated with PDXP recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>4 publications with PDXP and Lung
Brain Antibodies	>3 publications with PDXP and Brain
Vascular Antibodies	>2 publications with PDXP and Vascular
Liver Antibodies	>1 publications with PDXP and Liver
Muscle Antibodies	>1 publications with PDXP and Muscle
Embryonic Tissue Antibodies	>1 publications with PDXP and Embryonic Tissue
Blood Antibodies	>1 publications with PDXP and Blood