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PEA-15 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203400

Phospho-enriched protein in astrocytes 15 kDa (PEA-15) is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes. This protein has been implicated in the regulation of multiple… More details

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Product Overview

Online Datasheet in PDF
Product Name
PEA-15, Recombinant Protein
Full Product Name
PEA-15, 1-130aa, Human, E Coli
Product Synonym Names
Phosphoprotein enriched in astrocytes 15kD; Astrocytic phosphoprotein PEA-15; PEA15; PED; Phosphoprotein enriched in astrocytes; 15kD Astrocytic phosphoprotein PEA 15; Astrocytic phosphoprotein PEA15; HMAT 1; HMAT1; Homolog of mouse MAT 1 oncogene; Homolog of mouse MAT1 oncogene; HuMMAT 1H; HuMMAT1H; MAT 1; MAT 1H; MAT1; MAT1H; PEA 15; PEA15 protein; Phosphoprotein enriched in astrocytes 15; Phosphoprotein enriched in astrocytes 15kD; Phosphoprotein enriched in diabetes.
Sequence
MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE SHNKLDKDNL SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEDELDTKLT RIPSAKKYKD IIRQPSEEEI IKLAPPPKKA
Host
E Coli
Form/Format
Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 1 mM DTT, 10% glycerol
Purity/Purification
> 90% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
15 kDa (130aa), confirmed by MALDI-TOF.
OMIM
X86809 mRNA
3D Structure
ModBase 3D Structure for Q15121
Antigen Species
Human

Product Categories/Family for PEA-15 recombinant protein

Applications Tested/Suitable for PEA-15 recombinant protein
SDS-PAGE

Product References and Citations for PEA-15 recombinant protein

Beguinot F., et al. (2009) Am J Physiol Endocrinol Metab. 297 (3):E592-601.; ueno NT., et al. (2008) Cancer Res. 68 (22):9302-10.;

Other Notes

Small volumes of PEA-15 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PEA-15 purchase

MBS203400 is a recombinant protein targeting PEA-15. Also known as PEA-15, 1-130aa, Human, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PEA-15. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
astrocytic phosphoprotein PEA-15 isoform b
NCBI Official Synonym Full Names
proliferation and apoptosis adaptor protein 15
NCBI Official Symbol
PEA15
NCBI Official Synonym Symbols
PED; MAT1; HMAT1; MAT1H; PEA-15; HUMMAT1H; PED-PEA15; PED/PEA15
UniProt Protein Name
Astrocytic phosphoprotein PEA-15
UniProt Synonym Protein Names
15 kDa phosphoprotein enriched in astrocytes; Phosphoprotein enriched in diabetes; PED
UniProt Gene Name
PEA15
UniProt Synonym Gene Names
PED
NCBI Protein Information
astrocytic phosphoprotein PEA-15

NCBI Summary for PEA-15

This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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UniProt Comments for PEA-15

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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