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PTGR1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204591

PTGR1, also known as LTB4DH, belongs to the NADP-dependent oxidoreductase L4BD family. This enzyme catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic… More details

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Product Overview

Online Datasheet in PDF
Product Name
PTGR1, Recombinant Protein
Full Product Name
PTGR1, 1-329aa, Human, His tag, E Coli
Product Gene Name
Product Synonym Names
prostaglandin reductase 1; LTB4DH; PGR1; ZADH3
Sequence
MGSSHHHHHH SSGLVPRGSH MGSEFMVRTK TWTLKKHFVG YPTNSDFELK TAELPPLKNG EVLLEALFLT VDPYMRVAAK RLKEGDTMMG QQVAKVVESK NVALPKGTIV LASPGWTTHS ISDGKDLEKL LTEWPDTIPL SLALGTVGMP GLTAYFGLLE ICGVKGGETV MVNAAAGAVG SVVGQIAKLK GCKVVGAVGS DEKVAYLQKL GFDVVFNYKT VESLEETLKK ASPDGYDCYF DNVGGEFSNT VIGQMKKFGR IAICGAISTY NRTGPLPPGP PPEIVIYQEL RMEAFVVYRW QGDARQKALK DLLKWVLEGK IQYKEYIIEG FENMPAAFMG MLKGDNLGKT IVKA
Host
E Coli
Form/Format
Liquid. In 20 mM Tris-HCl Buffer, pH7.5, 10% glycerol, 1mM DTT, 200mM NaCl
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at +2C to +8C for 1 week. For long term storage
aliquot and store at -20C to -80C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
38.6kDa (354aa), confirmed by MALDI-TOF
OMIM
AK289597 mRNA
3D Structure
ModBase 3D Structure for Q14914
Antigen Species
Human
Tag Information
His-tag
Domain
1-329aa

Product Categories/Family for PTGR1 recombinant protein

Applications Tested/Suitable for PTGR1 recombinant protein
SDS-PAGE

SDS-PAGE of PTGR1 recombinant protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain
PTGR1 Recombinant Protein – Cat# MBS204591

Product References and Citations for PTGR1 recombinant protein

Yokomizo T., et al. (1996) J. Biol. Chem. 271:2844-2850; Tai, H.H., et al. (2002). Prostaglandins Other Lipid Mediat. 68-69: 483-493.

Other Notes

Small volumes of PTGR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTGR1 purchase

MBS204591 is a recombinant protein targeting PTGR1. Also known as PTGR1, 1-329aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PTGR1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
prostaglandin reductase 1 isoform 1
NCBI Official Synonym Full Names
prostaglandin reductase 1
NCBI Official Symbol
PTGR1
NCBI Official Synonym Symbols
PGR1; ZADH3; LTB4DH
UniProt Protein Name
Prostaglandin reductase 1
UniProt Synonym Protein Names
15-oxoprostaglandin 13-reductase (EC:1.3.1.48); NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC:1.3.1.74)
UniProt Gene Name
PTGR1
UniProt Synonym Gene Names
LTB4DH; PRG-1
NCBI Protein Information
prostaglandin reductase 1

NCBI Summary for PTGR1

This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
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UniProt Comments for PTGR1

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PTGR1 recombinant protein

 Reference Product  PubMed Publications
 LTA4H recombinant protein  >2 publications with PTGR1 and LTA4H
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