RAB14 Human Recombinant Protein

RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]

RAB14: a protein of the GTPase superfamily, Rab family. May be involved in vesicular trafficking and neurotransmitter release. Localized to the inner face of the cell membrane by a lipid-anchor.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 9q33.2

Cellular Component: Golgi apparatus; Golgi stack; cytoplasmic vesicle membrane; nuclear envelope-endoplasmic reticulum network; intracellular membrane-bound organelle; rough endoplasmic reticulum; lysosomal membrane; lysosome; early endosome; phagocytic vesicle; cytosol; Golgi membrane; trans-Golgi network transport vesicle; recycling endosome; phagocytic vesicle membrane; perinuclear region of cytoplasm; early endosome membrane; late endosome; plasma membrane; intracellular

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; myosin V binding

Biological Process: vesicle-mediated transport; intracellular protein transport; embryonic development; intracellular transport; fibroblast growth factor receptor signaling pathway; regulation of protein localization; metabolic process; Golgi to endosome transport; Rab protein signal transduction; endocytic recycling