Human ROR1 Recombinant Protein – Cat# MBS1884070

Figure 1. Human ROR1(30-164) Protein, hFc Tag on SDS-PAGE under reducing condition.

ROR1 Human Recombinant Protein

Name: ROR1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1884070
Price: 340 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1884070

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a… More details

$340 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ROR1, Recombinant Protein

Full Product Name

Human ROR1 (30-164) Protein, hFc Tag

Product Gene Name

ROR1 recombinant protein

Product Synonym Names

NTRKR1; dJ537F10.1; Recombinant human ROR1 (30-164) Protein with C-terminal human Fc tag

Sequence

ROR1 (Gln30-Tyr 164) hFc (Glu99-Ala 330)

Host

HEK293

Form/Format

Lyophilized from sterile PBS, pH 7.4. Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Purity/Purification

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Preparation and Storage

Store at -20 degree C to -80 degree C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 degree C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Molecular Weight

937

OMIM

602336

3D Structure

ModBase 3D Structure for Q01973

Tag

C-Human Fc

Product Categories/Family for ROR1 recombinant protein

ECD Proteins

Other Notes

Small volumes of ROR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ROR1 purchase

MBS1884070 is a recombinant protein targeting ROR1. Also known as Human ROR1 (30-164) Protein, hFc Tag. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for ROR1. It may not necessarily be applicable to this product.

NCBI GI #

118572711

NCBI GeneID

4919

NCBI Accession #

Q01973.2

UniProt Primary Accession #

Q01973

UniProt Secondary Accession #

Q5VVX6; Q66K77; Q92776

UniProt Related Accession #

Q01973

NCBI Official Full Name

Tyrosine-protein kinase transmembrane receptor ROR1

NCBI Official Synonym Full Names

receptor tyrosine kinase-like orphan receptor 1

NCBI Official Symbol

ROR1

NCBI Official Synonym Symbols

NTRKR1; dJ537F10.1

UniProt Protein Name

Tyrosine-protein kinase transmembrane receptor ROR1

UniProt Synonym Protein Names

Neurotrophic tyrosine kinase, receptor-related 1

Protein Family

Inactive tyrosine-protein kinase transmembrane receptor

UniProt Gene Name

ROR1

UniProt Synonym Gene Names

NTRKR1

UniProt Entry Name

ROR1_HUMAN

NCBI Protein Information

tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor-related 1

UniProt Comments for ROR1

ROR1: Tyrosine-protein kinase receptor whose role is not yet clear. Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; Kinase, protein; TK group; Ror family

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; receptor complex

Molecular Function: Wnt-protein binding; protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway

Research Articles on ROR1

1. Data shows that ROR1 and ROR2 are inversely expressed in melanomas and negatively regulate each other. Also, hypoxia initiates a shift of ROR1-positive melanomas to a more invasive, ROR2-positive phenotype.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ROR1 recombinant protein

Reference Product	PubMed Publications
WNT5A recombinant protein	>19 publications with ROR1 and WNT5A
EGFR recombinant protein	>4 publications with ROR1 and EGFR
SRC recombinant protein	>4 publications with ROR1 and SRC
NKX2-1 recombinant protein	>1 publications with ROR1 and NKX2-1
ERBB3 recombinant protein	>1 publications with ROR1 and ERBB3

Pathways associated with ROR1 recombinant protein

Products by Pathway	Pathway Diagram
Nuclear Receptors Pathway antibodies	Nuclear Receptors Pathway Diagram
PCP/CE Pathway antibodies	PCP/CE Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By Wnt Pathway antibodies	Signaling By Wnt Pathway Diagram
WNT5A-dependent Internalization Of FZD2, FZD5 And ROR2 Pathway antibodies	WNT5A-dependent Internalization Of FZD2, FZD5 And ROR2 Pathway Diagram
Beta-catenin Independent WNT Signaling Pathway antibodies	Beta-catenin Independent WNT Signaling Pathway Diagram

Diseases associated with ROR1 recombinant protein

Disease Name	Pubmed Publications
Lymphoma Antibodies	>21 publications with ROR1 and Lymphoma
Lung Neoplasms Antibodies	>5 publications with ROR1 and Lung Neoplasms
Adenocarcinoma Antibodies	>5 publications with ROR1 and Adenocarcinoma
Neoplasms, Experimental Antibodies	>5 publications with ROR1 and Neoplasms, Experimental
Breast Neoplasms Antibodies	>4 publications with ROR1 and Breast Neoplasms
Inflammation Antibodies	>3 publications with ROR1 and Inflammation
Lung Diseases Antibodies	>3 publications with ROR1 and Lung Diseases
Disease Models, Animal Antibodies	>3 publications with ROR1 and Disease Models, Animal
Liver Diseases Antibodies	>2 publications with ROR1 and Liver Diseases
Liver Neoplasms Antibodies	>2 publications with ROR1 and Liver Neoplasms

Organs/Tissues associated with ROR1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>23 publications with ROR1 and Blood
Brain Antibodies	>17 publications with ROR1 and Brain
Embryonic Tissue Antibodies	>14 publications with ROR1 and Embryonic Tissue
Lung Antibodies	>12 publications with ROR1 and Lung
Bone Antibodies	>12 publications with ROR1 and Bone
Heart Antibodies	>6 publications with ROR1 and Heart
Stomach Antibodies	>4 publications with ROR1 and Stomach
Lymph Node Antibodies	>4 publications with ROR1 and Lymph Node
Eye Antibodies	>4 publications with ROR1 and Eye
Prostate Antibodies	>3 publications with ROR1 and Prostate