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SGPL1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS638196

SGPL1 (Sphingosine-1-phosphate lyase 1) cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. SGPL1 elevates stress-induced ceramide production and apoptosis. SGPL1 is a Type III membrane… More details

$1250 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SGPL1, Recombinant Protein
Full Product Name
SGPL1, Recombinant, Human (SPL 59-E, FLJ13811, hSPL, KIAA1252, Sphingosine-1-phosphate aldolase, Sphingosine-1-phosphate lyase 1, SPL, SP-lyase, sphingosine-1-phosphate lyase 1)
Product Gene Name
Sgpl1 recombinant protein
Form/Format
Supplied as a liquid in 25mM Tris-HCl, pH 8.0, 100mM NaCl, 0.05% Tween-20, 10% glycerol, 3 mM DTT, 0.5mM pyridoxal 5' phosphate monohydrate.
Purity/Purification
Purified
0.7
Preparation and Storage
Aliquot to avoid repeated freezing and thawing and store at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.
Molecular Weight
57.5kD
Chromosome Location
Chromosome: 10; NC_000076.6 (61098642..61147665, complement). Location: 10 B4; 10 32.14 cM
3D Structure
ModBase 3D Structure for Q8R0X7

Product Categories/Family for Sgpl1 recombinant protein

Molecular Biology; MB-Proteins
Application Notes for Sgpl1 recombinant protein
Useful for the study of of biochemical function.

Testing Data of Sgpl1 recombinant protein

SGPL1 Recombinant Protein – Cat# MBS638196

Other Notes

Small volumes of Sgpl1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Sgpl1 purchase

MBS638196 is a recombinant protein targeting Sgpl1. Also known as SGPL1, Recombinant, Human (SPL 59-E, FLJ13811, hSPL, KIAA1252, Sphingosine-1-phosphate aldolase, Sphingosine-1-phosphate lyase 1, SPL, SP-lyase, sphingosine-1-phosphate lyase 1).

Additional Details

NCBI/Uniprot data below describe general gene information for Sgpl1. It may not necessarily be applicable to this product.

NCBI GI #
31543694
NCBI GeneID
20397
NCBI Accession #
NP_033189.2
UniProt Primary Accession #
Q8R0X7
UniProt Secondary Accession #
O54955; Q8C942
UniProt Related Accession #
Q8R0X7
GenBank Nucleotide #
NM_009163.3
NCBI Official Full Name
sphingosine-1-phosphate lyase 1
NCBI Official Synonym Full Names
sphingosine phosphate lyase 1
NCBI Official Symbol
Sgpl1
NCBI Official Synonym Symbols
Spl; S1PL; AI428538; D10Xrf456
UniProt Protein Name
Sphingosine-1-phosphate lyase 1
UniProt Synonym Protein Names
Sphingosine-1-phosphate aldolase
Protein Family
Sphingosine-1-phosphate lyase
UniProt Gene Name
Sgpl1
UniProt Synonym Gene Names
S1PL; SP-lyase 1; SPL 1; mSPL
UniProt Entry Name
SGPL1_MOUSE
NCBI Protein Information
sphingosine-1-phosphate lyase 1; mSPL; SPL 1; SP-lyase 1; sphingosine-1-phosphate aldolase

UniProt Comments for Sgpl1

SGPL1: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.

Protein type: Apoptosis; EC 4.1.2.27; Lyase; Lipid Metabolism - sphingolipid; Membrane protein, integral

Cellular Component: membrane; endoplasmic reticulum; integral to membrane

Molecular Function: sphinganine-1-phosphate aldolase activity; lyase activity; carboxy-lyase activity; catalytic activity; pyridoxal phosphate binding

Biological Process: estrogen metabolic process; sphingolipid metabolic process; apoptosis; androgen metabolic process; carboxylic acid metabolic process; regulation of multicellular organism growth; platelet-derived growth factor receptor signaling pathway; palate development; fatty acid metabolic process; sphingolipid catabolic process; post-embryonic development; nitrogen compound metabolic process; Leydig cell differentiation; skeletal morphogenesis; luteinization; hemopoiesis; spermatogenesis; lipid metabolic process; vasculogenesis; kidney development; ceramide metabolic process; female gonad development
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Research Articles on Sgpl1

1. Inducible Sgpl1 knockout mice are protected in experimental autoimmune encephalomyelitis (EAE).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Sgpl1 recombinant protein

 Products by Pathway  Pathway Diagram
 Kennedy Pathway antibodies  Kennedy Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Sphingolipid De Novo Biosynthesis Pathway antibodies  Sphingolipid De Novo Biosynthesis Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipids Metabolism Pathway antibodies  Sphingolipids Metabolism Pathway Diagram
 Sphingosine Degradation Pathway antibodies  Sphingosine Degradation Pathway Diagram
 Sphingosine Degradation Pathway antibodies  Sphingosine Degradation Pathway Diagram

Diseases associated with Sgpl1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with Sgpl1 and Neoplasms
 Nervous System Diseases Antibodies  >2 publications with Sgpl1 and Nervous System Diseases
 Carcinoma Antibodies  >2 publications with Sgpl1 and Carcinoma
 Atherosclerosis Antibodies  >1 publications with Sgpl1 and Atherosclerosis
 Ovarian Diseases Antibodies  >1 publications with Sgpl1 and Ovarian Diseases
 Liver Neoplasms Antibodies  >1 publications with Sgpl1 and Liver Neoplasms
 Atrophy Antibodies  >1 publications with Sgpl1 and Atrophy

Organs/Tissues associated with Sgpl1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Olfactory Mucosa Antibodies  >2 publications with Sgpl1 and Olfactory Mucosa
 Bone Marrow Antibodies  >1 publications with Sgpl1 and Bone Marrow
 Skin Antibodies  >1 publications with Sgpl1 and Skin
 Bone Antibodies  >1 publications with Sgpl1 and Bone
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