SIV gp120 Recombinant Protein

6xHis tagged gp120 (SIV/mac251)(isolate SIVmac251v31523ru28) (aa 31-528)(Genebank No. GU952740)purified from 293 cell culture

Envelope protein gp120 expressed and purified from 293 cell culture.

Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope. The 120 in its name comes from its molecular weight of 120. Gp120 is essential for virus entry into cells as it plays a vital role in attachment to specific cell surface receptors. These receptors are DC-SIGN, Heparan Sulfate Proteoglycan and a specific interaction with the CD4 receptor, particularly on helper T-cells. Binding to CD4 induces the start of a cascade of conformational changes in gp120 and gp41 that lead to the fusion of the viral with the host cell membrane. Binding to CD4 is mainly electrostatic although there are van der Waals interactions and hydrogen bonds.

1. Stone, M., etc. A limited number of simian immunodeficiency virus (SIV) env variants are transmitted to rhesus macaques vaginally inoculated with SIVmac251. J. Virol. 84 (14), 7083-7095 (2010).
2. Manrique, M., etc. Resistance to infection, early and persistent suppression of SIVmac251 viremia and significant reduction of tissue viral burden after mucosal vaccination in females Rhesus macaques. J Virol. 2013 Oct 23

Small volumes of SIV gp120 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS434203 is a recombinant protein targeting SIV gp120. Also known as SIV gp120 (Isolate SIVmac251v31523ru28) (aa 31-528). Host: 293 cell culture.