STEAP4 Recombinant Protein

Name: STEAP4 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205595
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205595

STEAP4 belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe (3+) to Fe (2+) and Cu (2+) to Cu (1+),using NAD (+) as… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

STEAP4, Recombinant Protein

Full Product Name

STEAP4, 1-152aa, Human, His tag, E Coli (Denatured)

Product Gene Name

STEAP4 recombinant protein

Product Synonym Names

tumor necrosis factor alpha-induced protein 9; tumor necrosis factor; alpha-induced protein 9; DKFZp666D049; FLJ23153; STAMP2; TIARP; TNFAIP9

Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMEKT CIDALPLTMN SSEKQETVCI FGTGDFGRSL GLKMLQCGYS VVFGSRNPQK TTLLPSGAEV LSYSEAAKKS GIIIIAIHRE HYDFLTELTE VLNGKILVDI SNNLKINQYP ESNAEYLAHL VPGAHVVKAF NTISAWALQS GALDASRQ

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

20.6kDa (188aa)

OMIM

AF423422 mRNA

3D Structure

ModBase 3D Structure for Q687X5

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for STEAP4 recombinant protein

Cancer

Applications Tested/Suitable for STEAP4 recombinant protein

SDS-PAGE

Application Notes for STEAP4 recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for STEAP4 recombinant protein

Kim,H.Y, et al. (2012) Exp. Mol. Med. 44 (10), 622-632; Tanaka,Y., et al. (2012) Clin. Exp. Rheumatol. 30 (1), 99-102;

Other Notes

Small volumes of STEAP4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STEAP4 purchase

MBS205595 is a recombinant protein targeting STEAP4. Also known as STEAP4, 1-152aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for STEAP4. It may not necessarily be applicable to this product.

NCBI GI #

100815815

NCBI GeneID

79689

NCBI Accession #

NP_078912

UniProt Primary Accession #

Q687X5

UniProt Secondary Accession #

Q658Q9; Q687X4; Q8WWB0; Q9H5R1

UniProt Related Accession #

Q687X5

GenBank Nucleotide #

NM_024636.3

NCBI Official Full Name

metalloreductase STEAP4 isoform 1

NCBI Official Synonym Full Names

STEAP4 metalloreductase

NCBI Official Symbol

STEAP4

NCBI Official Synonym Symbols

TIARP; STAMP2; SchLAH; TNFAIP9

UniProt Protein Name

Metalloreductase STEAP4

UniProt Synonym Protein Names

Six-transmembrane epithelial antigen of prostate 4; SixTransMembrane protein of prostate 2; Tumor necrosis factor, alpha-induced protein 9

Protein Family

Metalloreductase

UniProt Gene Name

STEAP4

UniProt Synonym Gene Names

STAMP2; TNFAIP9

NCBI Protein Information

metalloreductase STEAP4

NCBI Summary for STEAP4

The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

UniProt Comments for STEAP4

Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+ (). Uses NADP+ as acceptor (). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193).

Research Articles on STEAP4

1. STEAP4 plays role in metal homeostasis is critical to the maintenance of cellular homeostasis , and in preventing the onset of metabolic disease. [review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with STEAP4 recombinant protein

Reference Product	PubMed Publications
TNF recombinant protein	>10 publications with STEAP4 and TNF
IL6 recombinant protein	>2 publications with STEAP4 and IL6
EEA1 recombinant protein	>2 publications with STEAP4 and EEA1

Pathways associated with STEAP4 recombinant protein

Products by Pathway	Pathway Diagram
Copper Homeostasis Pathway antibodies	Copper Homeostasis Pathway Diagram

Diseases associated with STEAP4 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>25 publications with STEAP4 and Inflammation
Necrosis Antibodies	>17 publications with STEAP4 and Necrosis
Hypertension Antibodies	>5 publications with STEAP4 and Hypertension
Cardiovascular Diseases Antibodies	>5 publications with STEAP4 and Cardiovascular Diseases
Disease Models, Animal Antibodies	>5 publications with STEAP4 and Disease Models, Animal
Prostatic Neoplasms Antibodies	>5 publications with STEAP4 and Prostatic Neoplasms
Heart Diseases Antibodies	>3 publications with STEAP4 and Heart Diseases
Liver Diseases Antibodies	>3 publications with STEAP4 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>2 publications with STEAP4 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>2 publications with STEAP4 and Liver Neoplasms

Organs/Tissues associated with STEAP4 recombinant protein

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>45 publications with STEAP4 and Prostate
Blood Antibodies	>22 publications with STEAP4 and Blood
Connective Tissue Antibodies	>12 publications with STEAP4 and Connective Tissue
Liver Antibodies	>7 publications with STEAP4 and Liver
Skin Antibodies	>4 publications with STEAP4 and Skin
Bone Antibodies	>3 publications with STEAP4 and Bone
Lung Antibodies	>2 publications with STEAP4 and Lung
Kidney Antibodies	>1 publications with STEAP4 and Kidney
Testis Antibodies	>1 publications with STEAP4 and Testis
Cervix Antibodies	>1 publications with STEAP4 and Cervix