Tapasin (TAPBP) Chicken Recombinant Protein

Function: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading)

By similarity.

Subunit structure: Interacts with TAP1 and is thus a subunit of the TAP complex. Interaction with TAP1 is TAP2 independent and is required for efficient peptide-TAP interaction. Obligatory mediator for the interaction between newly assembled MHC class I molecules, clareticulin, ERp57 and TAP. Up to 4 MHC class I/tapasin complexes bind to 1 TAP

By similarity.

Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein

Probable.

Domain: The N-terminus is required for efficient association with MHC class I molecule and for a stable interaction between MHC I and calreticulin. Binding to TAP is mediated by the C-terminus region

By similarity.

Sequence similarities: Contains 1 Ig-like C1-type (immunoglobulin-like) domain.