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TLR3 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8122574

Background: Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3/CD283 plays a fundamental role in pathogen recognition… More details

$415 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TLR3, Recombinant Protein
Full Product Name
TLR3 Protein, Mouse, Recombinant (His Tag)
Product Gene Name
TLR3 recombinant protein
Product Synonym Names
Mouse TLR3/CD283 Protein (His Tag); AI957183 Protein, Mouse; Tlr3 Protein, Mouse; toll like receptor 3
Sequence
Met1-Leu70 5
Host
HEK293 Cells
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Purity/Purification
>97% as determined by SDS-PAGE
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
Molecular Weight
103,671 Da
3D Structure
ModBase 3D Structure for Q99MB1
Species
Mouse
Endotoxin
<1.0EU per ug of the protein as determined by the LAL method
Predicted N Terminal
Thr 26
Tag
C-His
Protein Construction
A DNA sequence encoding the extracellular domain of mouse TLR3 (NP_569054.2)(Met 1-Leu 705) was expressed with a C-terminal polyhistidine tag.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Product Categories/Family for TLR3 recombinant protein

Neuroinflammation Cancer Drug Targets

SDS-Page of TLR3 recombinant protein

TLR3 Recombinant Protein – Cat# MBS8122574

Product References and Citations for TLR3 recombinant protein

Muzio M, et al.. (2000) Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J Immunol. 164(11): 5998-6004.
Doyle S, et al.. (2002) IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity. 17(3): 251-63.
Choe J, et al.. (2005) Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science. 309(5734): 581-5.

Other Notes

Small volumes of TLR3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLR3 purchase

MBS8122574 is a recombinant protein targeting TLR3. Also known as TLR3 Protein, Mouse, Recombinant (His Tag). Host: HEK293 Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for TLR3. It may not necessarily be applicable to this product.

NCBI GI #
31543872
NCBI GeneID
142980
NCBI Accession #
NP_569054.2
UniProt Primary Accession #
Q99MB1
UniProt Secondary Accession #
Q91ZM4
UniProt Related Accession #
Q99MB1
GenBank Nucleotide #
NM_126166.4
NCBI Official Full Name
toll-like receptor 3
NCBI Official Synonym Full Names
toll-like receptor 3
NCBI Official Symbol
Tlr3
NCBI Official Synonym Symbols
AI957183
UniProt Protein Name
Toll-like receptor 3
UniProt Synonym Protein Names
CD_antigen: CD283
Protein Family
Toll-like receptor
UniProt Gene Name
Tlr3
UniProt Entry Name
TLR3_MOUSE
NCBI Protein Information
toll-like receptor 3

UniProt Comments for TLR3

TLR3: a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: cell surface; membrane; lysosomal membrane; endoplasmic reticulum; cytoplasm; integral to membrane; intracellular; endosome

Molecular Function: identical protein binding; protein binding; transmembrane receptor activity; RNA binding; double-stranded RNA binding; receptor activity

Biological Process: positive regulation of interleukin-12 production; positive regulation of JNK cascade; microglial cell activation; positive regulation of interferon-alpha biosynthetic process; defense response; positive regulation of NF-kappaB import into nucleus; toll-like receptor 3 signaling pathway; signal transduction; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; response to exogenous dsRNA; positive regulation of interferon type I production; positive regulation of interferon-beta production; inflammatory response; defense response to virus; positive regulation of cytokine production; positive regulation of I-kappaB kinase/NF-kappaB cascade; immune system process; MyD88-independent toll-like receptor signaling pathway; response to virus; response to dsRNA; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor signaling pathway; positive regulation of chemokine production; positive regulation of chemokine biosynthetic process; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; I-kappaB phosphorylation; positive regulation of inflammatory response; microglial cell activation during immune response; positive regulation of interferon-gamma biosynthetic process
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Research Articles on TLR3

1. Ischemic preconditioning-induced ischemic tolerance is mediated by astrocytic TLR3 signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with TLR3 recombinant protein

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 IKK Complex Recruitment Mediated By RIP1 Pathway antibodies  IKK Complex Recruitment Mediated By RIP1 Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram

Diseases associated with TLR3 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >608 publications with TLR3 and Inflammation
 Necrosis Antibodies  >369 publications with TLR3 and Necrosis
 Lung Diseases Antibodies  >128 publications with TLR3 and Lung Diseases
 Asthma Antibodies  >88 publications with TLR3 and Asthma
 Kidney Diseases Antibodies  >64 publications with TLR3 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >45 publications with TLR3 and Neoplasms, Experimental
 Respiratory Hypersensitivity Antibodies  >40 publications with TLR3 and Respiratory Hypersensitivity
 Adenocarcinoma Antibodies  >39 publications with TLR3 and Adenocarcinoma
 Encephalitis, Herpes Simplex Antibodies  >35 publications with TLR3 and Encephalitis, Herpes Simplex
 Heart Diseases Antibodies  >34 publications with TLR3 and Heart Diseases

Organs/Tissues associated with TLR3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >226 publications with TLR3 and Lung
 Brain Antibodies  >130 publications with TLR3 and Brain
 Spleen Antibodies  >120 publications with TLR3 and Spleen
 Skin Antibodies  >97 publications with TLR3 and Skin
 Eye Antibodies  >63 publications with TLR3 and Eye
 Embryonic Tissue Antibodies  >31 publications with TLR3 and Embryonic Tissue
 Oviduct Antibodies  >9 publications with TLR3 and Oviduct
 Dorsal Root Ganglion Antibodies  >6 publications with TLR3 and Dorsal Root Ganglion
 Ovary Antibodies  >5 publications with TLR3 and Ovary
 Bladder Antibodies  >3 publications with TLR3 and Bladder
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