Human TOMM22 Recombinant Protein – Cat# MBS1578094

SDS PAGE for Recombinant Human TOMM22 protein

TOMM22 Human Recombinant Protein

Name: TOMM22 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1578094
Price: 435 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1578094

MBS1578094 is a recombinant protein targeting TOMM22. Also known as Recombinant Human TOMM22 Protein, N-GST & C-His. Host: E coli. More details

$435 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TOMM22, Recombinant Protein

Full Product Name

Recombinant Human TOMM22 Protein, N-GST & C-His

Product Gene Name

TOMM22 recombinant protein

Product Synonym Names

1C9-2; TOM22; Translocase of outer membrane 22 kDa subunit homolog; hTom22; Mitochondrial import receptor subunit TOM22 homolog; TOMM22

Host

E coli

Form/Format

Lyophilized from a solution in PBS pH7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Purity/Purification

>90% as determined by SDS-PAGE

Preparation and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 degree C for one week. Store at -20 degree C for twelve months from the date of receipt.

Molecular Weight

142

Sequence Positions

Glu42-Ala84

OMIM

607046

3D Structure

ModBase 3D Structure for Q9NS69

Species

Human

Reconstitution

Reconstitute in sterile water for a stock solution.

Product Categories/Family for TOMM22 recombinant protein

Recombinant Proteins

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for TOMM22 recombinant protein

SDS-PAGE (SDS), Western Blot (WB), ELISA (EIA), Immunogen

Product References and Citations for TOMM22 recombinant protein

In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy. PMID: 29165030
A mitophagy-related gene signature associated with prognosis and immune microenvironment in colorectal cancer. PMID: 36333388
The prognostic value and clinical significance of mitophagy-related genes in hepatocellular carcinoma. PMID: 35991574
Mitochondrial accumulation of amyloid β (Aβ) peptides requires TOMM22 as a main Aβ receptor in yeast. PMID: 29925587
Knockdown of TMEM160 leads to an increase in reactive oxygen species generation and the induction of the mitochondrial unfolded protein response. PMID: 36217717

Other Notes

Small volumes of TOMM22 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TOMM22. It may not necessarily be applicable to this product.

NCBI GI #

24212074

NCBI GeneID

56993

NCBI Accession #

Q9NS69.3

UniProt Primary Accession #

Q9NS69

UniProt Related Accession #

Q9NS69

NCBI Official Full Name

Mitochondrial import receptor subunit TOM22 homolog

NCBI Official Synonym Full Names

translocase of outer mitochondrial membrane 22 homolog (yeast)

NCBI Official Symbol

TOMM22

NCBI Official Synonym Symbols

1C9-2; TOM22; MST065; MSTP065

UniProt Protein Name

Mitochondrial import receptor subunit TOM22 homolog

UniProt Synonym Protein Names

1C9-2; Translocase of outer membrane 22 kDa subunit homolog

UniProt Gene Name

TOMM22

UniProt Synonym Gene Names

TOM22; hTom22

UniProt Entry Name

TOM22_HUMAN

NCBI Protein Information

mitochondrial import receptor subunit TOM22 homolog; mitochondrial import receptor Tom22; translocase of outer membrane 22 kDa subunit homolog

NCBI Summary for TOMM22

The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008]

UniProt Comments for TOMM22

TOMM22: Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. Belongs to the Tom22 family.

Protein type: Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: mitochondrion; membrane; mitochondrial outer membrane translocase complex; mitochondrial inner membrane; integral to membrane

Molecular Function: protein binding; protein transmembrane transporter activity

Biological Process: cellular protein metabolic process; protein targeting to mitochondrion; protein import into mitochondrial outer membrane

Research Articles on TOMM22

1. Blockade of mitochondrial protein import triggers the recruitment of PARK2, by PINK1, to the TOMM machinery.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TOMM22 recombinant protein

Reference Product	PubMed Publications
TOMM20 recombinant protein	>7 publications with TOMM22 and TOMM20
TOMM40 recombinant protein	>2 publications with TOMM22 and TOMM40
TOMM70A recombinant protein	>1 publications with TOMM22 and TOMM70A

Pathways associated with TOMM22 recombinant protein

Products by Pathway	Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Mitochondrial Protein Import Pathway antibodies	Mitochondrial Protein Import Pathway Diagram

Diseases associated with TOMM22 recombinant protein

Disease Name	Pubmed Publications
Cell Transformation, Neoplastic Antibodies	>1 publications with TOMM22 and Cell Transformation, Neoplastic
Death Antibodies	>1 publications with TOMM22 and Death
Liver Diseases Antibodies	>1 publications with TOMM22 and Liver Diseases
Carcinoma Antibodies	>1 publications with TOMM22 and Carcinoma

Organs/Tissues associated with TOMM22 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>5 publications with TOMM22 and Liver
Prostate Antibodies	>1 publications with TOMM22 and Prostate
Embryonic Tissue Antibodies	>1 publications with TOMM22 and Embryonic Tissue
Muscle Antibodies	>1 publications with TOMM22 and Muscle