uSP46 Recombinant Protein

Name: uSP46 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205710
Price: 265 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205710

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. uSP46 belongs to a large family of cysteine proteases that function as… More details

$265 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

uSP46, Recombinant Protein

Full Product Name

uSP46, 1-366aa, Human, His tag, E Coli

Product Gene Name

uSP46 recombinant protein

Product Synonym Names

ubiquitin carboxyl-terminal hydrolase 46 isoform 1; Deubiquitinating enzyme 46; FLJ12552; ubiquitin carboxyl-terminal hydrolase 46; ubiquitin thioesterase 46; ubiquitin-specific-processing protease 46

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMTVRNIA SICNMGTNAS ALEKDIGPEQ FPINEHYFGL VNFGNTCYCN SVLQALYFCR PFRENVLAYK AQQKKKENLL TCLADLFHSI ATQKKKVGVI PPKKFISRLR KENDLFDNYM QQDAHEFLNY LLNTIADILQ EEKKQEKQNG KLKNGNMNEP AENNKPELTW VHEIFQGTLT NETRCLNCET VSSKDEDFLD LSVDVEQNTS ITHCLRDFSN TETLCSEQKY YCETCCSKQE AQKRMRVKKL PMILALHLKR FKYMEQLHRY TKLSYRVVFP LELRLFNTSS DAVNLDRMYD LVAVVVHCGS GPNRGHYITI VKSHGFWLLF DDDIVEKIDA QAIEEFYGLT SDISKNSESG YILFYQSRE

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.25 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

44.8kDa (389aa) confirmed by MALDI-TOF

OMIM

GU455414 mRNA

3D Structure

ModBase 3D Structure for P62068

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for uSP46 recombinant protein

Epigenomics (Transcription & Translation)

Applications Tested/Suitable for uSP46 recombinant protein

SDS-PAGE

Product References and Citations for uSP46 recombinant protein

Fukuo,Y., et al. (2011) J Affect Disord 133 (1-2), 150-157; Zhang,W., et al. (2011) PLoS ONE 6 (10), E26297;

Other Notes

Small volumes of uSP46 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for uSP46 purchase

MBS205710 is a recombinant protein targeting uSP46. Also known as uSP46, 1-366aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for uSP46. It may not necessarily be applicable to this product.

NCBI GI #

31377709

NCBI GeneID

64854

NCBI Accession #

NP_073743

UniProt Primary Accession #

P62068

UniProt Secondary Accession #

Q80V95; Q9H7U4; Q9H9T8; B7Z3Y7; B7Z675; B7Z7S3; G8ACC7

UniProt Related Accession #

P62068

GenBank Nucleotide #

NM_022832.3

NCBI Official Full Name

ubiquitin carboxyl-terminal hydrolase 46 isoform 1

NCBI Official Synonym Full Names

ubiquitin specific peptidase 46

NCBI Official Symbol

USP46

UniProt Protein Name

Ubiquitin carboxyl-terminal hydrolase 46

UniProt Synonym Protein Names

Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46

Protein Family

Ubiquitin carboxyl-terminal hydrolase

UniProt Gene Name

USP46

NCBI Protein Information

ubiquitin carboxyl-terminal hydrolase 46

NCBI Summary for uSP46

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009]

UniProt Comments for uSP46

Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014).

Research Articles on uSP46

1. Results suggest role for USP46/USP12 in Epstein-Barr virus induced growth transformation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with uSP46 recombinant protein

Reference Product	PubMed Publications
WDR48 recombinant protein	>5 publications with uSP46 and WDR48
WDR20 recombinant protein	>4 publications with uSP46 and WDR20
PHLPP1 recombinant protein	>3 publications with uSP46 and PHLPP1
SET recombinant protein	>2 publications with uSP46 and SET

Diseases associated with uSP46 recombinant protein

Disease Name	Pubmed Publications
Anemia Antibodies	>2 publications with uSP46 and Anemia
Abnormalities, Multiple Antibodies	>1 publications with uSP46 and Abnormalities, Multiple
Nerve Degeneration Antibodies	>1 publications with uSP46 and Nerve Degeneration
Disease Models, Animal Antibodies	>1 publications with uSP46 and Disease Models, Animal
Kidney Diseases Antibodies	>1 publications with uSP46 and Kidney Diseases

Organs/Tissues associated with uSP46 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>5 publications with uSP46 and Brain
Bone Antibodies	>1 publications with uSP46 and Bone
Parathyroid Antibodies	>1 publications with uSP46 and Parathyroid
Kidney Antibodies	>1 publications with uSP46 and Kidney
Skin Antibodies	>1 publications with uSP46 and Skin
Spleen Antibodies	>1 publications with uSP46 and Spleen