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GRO-Beta/MIP-2 (rGRO b) Rat Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS144089

Description: GRO-Beta Rat Recombinant also called Rat MIP-2 produced in E Coli is a single, non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7923 Dalton. The GRO-b is purified by proprietary chromatographic… More details

$250 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GRO-beta/MIP-2 (rGRO b), Active Protein
Full Product Name
Recombinant Rat GRO-beta/MIP-2 (CXCL2)
Product Gene Name
rGRO b active protein
Product Synonym Names
GRO b Rat; GRO-beta/MIP-2 Rat Recombinant (CXCL2); Macrophage inflammatory protein 2-alpha; MIP2-alpha; CXCL2; Growth- regulated protein beta; Gro-beta; chemokine (C-X-C motif) ligand 2; GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a; MGSA beta; CINC-3
Sequence
VVVASELRCQ CLTTLPRVDF KNIQSLTVTP PGPHCAQTEV IATLKDGHEV CLNPEAPLVQ RIVQKILNKG KAN
Host
E Coli
Form/Format
Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 99.0% as determined by SDS-PAGE.
Preparation and Storage
Lyophilized GRO-b although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CXCL2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Molecular Weight
10,783 Da
3D Structure
ModBase 3D Structure for P30348
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility
It is recommended to reconstitute the lyophilized GRO-beta Rat in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
The biological activity was determined by its ability to chemoattract total human neutrophils using a concentration range of 1.0-10.0 ng/ml, corresponding to a specific activity of 100,000-1,000,000 units/mg.

Product Categories/Family for rGRO b active protein

Chemokines; GRO

Other Notes

Small volumes of rGRO b active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for rGRO b purchase

MBS144089 is an active protein targeting rGRO b. Also known as Recombinant Rat GRO-beta/MIP-2 (CXCL2). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for rGRO b. It may not necessarily be applicable to this product.

NCBI GI #
16758460
NCBI GeneID
114105
NCBI Accession #
NP_446099.1
UniProt Primary Accession #
P30348
UniProt Secondary Accession #
Q5WA60
UniProt Related Accession #
P30348
GenBank Nucleotide #
NM_053647.1
NCBI Official Full Name
C-X-C motif chemokine 2
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 2
NCBI Official Symbol
Cxcl2
NCBI Official Synonym Symbols
Mip-2; Scyb2
UniProt Protein Name
C-X-C motif chemokine 2
UniProt Synonym Protein Names
Cytokine-induced neutrophil chemoattractant 3; CINC-3; Macrophage inflammatory protein 2; MIP2
UniProt Gene Name
Cxcl2
UniProt Synonym Gene Names
Cinc3; Mip-2; Mip2; Scyb2; CINC-3; MIP2
UniProt Entry Name
CXCL2_RAT
NCBI Protein Information
C-X-C motif chemokine 2; CINC-3; MIP2; cytokine-induced neutrophil chemoattractant 3; macrophage inflammatory protein 2; small inducible cytokine subfamily, member 2

NCBI Summary for rGRO b

chemokine involved in the pulmonary inflammatory response [RGD, Feb 2006]

UniProt Comments for rGRO b

CXCL3: Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: neutrophil chemotaxis; wound healing; leukocyte chemotaxis; response to glucocorticoid stimulus; response to amphetamine; positive regulation of leukocyte chemotaxis; response to estradiol stimulus; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; response to heat; response to molecule of bacterial origin; response to gamma radiation; immune response; inflammatory response
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Research Articles on rGRO b

1. IL-1beta-mediated regulation of the CXCL1 and CXCL2 genes in pancreatic beta-cells requires stimulus-induced changes in histone chemical modifications, recruitment of the NF-kappaB and STAT1 transcription factors to genomic regulatory sequences within the proximal gene promoters, and increases in phosphorylated forms of RNA polymerase II.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with rGRO b active protein

 Reference Product  PubMed Publications
 Cxcl1 active protein  >569 publications with rGRO b and Cxcl1
 Ccl2 active protein  >380 publications with rGRO b and Ccl2
 Il8rb active protein  >121 publications with rGRO b and Il8rb
 Cxcl3 active protein  >100 publications with rGRO b and Cxcl3
 Cxcr4 active protein  >44 publications with rGRO b and Cxcr4
 Ccr2 active protein  >42 publications with rGRO b and Ccr2
 Cxcl6 active protein  >37 publications with rGRO b and Cxcl6
 Ccr1 active protein  >26 publications with rGRO b and Ccr1
 Cxcr3 active protein  >18 publications with rGRO b and Cxcr3
 Ppbp active protein  >3 publications with rGRO b and Ppbp

Pathways associated with rGRO b active protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram

Diseases associated with rGRO b active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1033 publications with rGRO b and Inflammation
 Necrosis Antibodies  >652 publications with rGRO b and Necrosis
 Lung Diseases Antibodies  >391 publications with rGRO b and Lung Diseases
 Disease Models, Animal Antibodies  >366 publications with rGRO b and Disease Models, Animal
 Lung Injury Antibodies  >265 publications with rGRO b and Lung Injury
 Pneumonia Antibodies  >175 publications with rGRO b and Pneumonia
 Reperfusion Injury Antibodies  >115 publications with rGRO b and Reperfusion Injury
 Wounds and Injuries Antibodies  >98 publications with rGRO b and Wounds and Injuries
 Edema Antibodies  >96 publications with rGRO b and Edema
 Skin Diseases Antibodies  >84 publications with rGRO b and Skin Diseases

Organs/Tissues associated with rGRO b active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >637 publications with rGRO b and Lung
 Connective Tissue Antibodies  >28 publications with rGRO b and Connective Tissue
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