GHRH (SLIB) Active Protein

Name: SLIB Active Protein; GHRH; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS844874
Price: 390 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844874

Background: The recombinant human GHRH is a single, non-glycosylated, polypeptide chain containing 29 amino acids and having a molecular mass of 3358 Dalton. Corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GHRH (SLIB), Active Protein

Full Product Name

GHRH, human recombinant

Product Gene Name

SLIB active protein

Product Synonym Names

Somatoliberin; Growth hormone-releasing factor; GRF; Growth hormone-releasing hormone; GHRH; Somatocrinin; Somatorelin; Sermorelin; GHRF; MGC119781

Host

E Coli

Form/Format

Lyophilized powder
Appearance: Lyophilized protein

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

3.358 kDa

OMIM

139190

3D Structure

ModBase 3D Structure for P01286

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml

Endotoxin Level

<0.1 ng/mug

Biological Activity

MyBioSource's hGHRH is fully biologically active, increases plasma growth hormone concentrations by directly stimulating the anterior pituitary gland to release natural human growth hormone.

Handling

Centrifuge the vial prior to opening.

Applications Tested/Suitable for SLIB active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of SLIB active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLIB purchase

MBS844874 is an active protein targeting SLIB. Also known as GHRH, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SLIB. It may not necessarily be applicable to this product.

NCBI GI #

296080717

NCBI GeneID

2691

NCBI Accession #

NP_001171660.1

UniProt Primary Accession #

P01286

UniProt Secondary Accession #

Q4KN10; Q5JYR1

UniProt Related Accession #

P01286

GenBank Nucleotide #

NM_001184731.1

NCBI Official Full Name

somatoliberin isoform 2 preproprotein

NCBI Official Synonym Full Names

growth hormone releasing hormone

NCBI Official Symbol

GHRH

NCBI Official Synonym Symbols

GRF; INN; GHRF

UniProt Protein Name

Somatoliberin

UniProt Synonym Protein Names

Growth hormone-releasing factor; GRF; Growth hormone-releasing hormone; GHRH; Somatocrinin; Somatorelin; INN: Sermorelin

Protein Family

Growth hormone-releasing hormone receptor

UniProt Gene Name

GHRH

UniProt Synonym Gene Names

GHRF; GRF; GHRH

UniProt Entry Name

SLIB_HUMAN

NCBI Protein Information

somatoliberin

NCBI Summary for SLIB

The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. [provided by RefSeq, Jul 2008]

UniProt Comments for SLIB

GHRH: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. Belongs to the glucagon family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q11.2

Cellular Component: extracellular space; extracellular region; terminal button

Molecular Function: growth hormone-releasing hormone activity; growth hormone-releasing hormone receptor binding

Biological Process: response to food; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of growth hormone secretion; growth hormone secretion; cAMP-mediated signaling; positive regulation of circadian sleep/wake cycle, REM sleep; cell-cell signaling; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; adenohypophysis development; positive regulation of multicellular organism growth; G-protein signaling, adenylate cyclase activating pathway

Research Articles on SLIB

1. case Report: multiple endocrine neoplasia type 1 family characterized by primary hyperparathyroidism, in association with acromegaly because of ectopic GHRH secretion by a pancreatic neuroendocrine tumor in a young man.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.