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DR6 (TNFRSF21) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8122646

Background: TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic… More details

$415 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DR6 (TNFRSF21), Active Protein
Full Product Name
DR6 Protein, Mouse, Recombinant (His Tag)
Product Gene Name
TNFRSF21 active protein
Product Synonym Names
Mouse DR6/TNFRSF21 Protein (His Tag); AA959878 Protein, Mouse; DR6 Protein, Mouse; R74815 Protein, Mouse; TR7 Protein, Mouse; tumor necrosis factor receptor superfamily, member 21
Sequence
Met1-His34 9
Host
HEK293 Cells
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Purity/Purification
>95% as determined by SDS-PAGE
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
Molecular Weight
71,983 Da
3D Structure
ModBase 3D Structure for Q9EPU5
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Mouse
Endotoxin
<1.0EU per ug of the protein as determined by the LAL method
Predicted N Terminal
Gln 42
Tag
C-His
Protein Construction
A DNA sequence encoding the mouse TNFRSF21 (NP_848704.1) extracellular domain (Met 1-His 349) was fused with a polyhistidine tag at the C-terminus.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Activity
Immobilized mouse TNFRSF21-His at 10ug/ml (100uL/well) can bind biotinylated human APP-Fc with a linear range of 0.31-5ug/ml.

Product Categories/Family for TNFRSF21 active protein

Death Receptor Signaling

SDS-Page of TNFRSF21 active protein

TNFRSF21 Active Protein – Cat# MBS8122646

Product References and Citations for TNFRSF21 active protein

Pan G, et al. (1998) Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 431(3): 351-6.Benschop R, et al. (2009) Tumor necrosis factor receptor superfamily member 21: TNFR-related death receptor-6, DR6. Adv Exp Med Biol. 647: 186-94.Klma M, et al. (2009) Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta. 1793(10): 1579-87.

Other Notes

Small volumes of TNFRSF21 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF21 purchase

MBS8122646 is an active protein targeting TNFRSF21. Also known as DR6 Protein, Mouse, Recombinant (His Tag). Host: HEK293 Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF21. It may not necessarily be applicable to this product.

NCBI GI #
30519885
NCBI GeneID
94185
NCBI Accession #
NP_848704.1
UniProt Primary Accession #
Q9EPU5
UniProt Secondary Accession #
Q3UYG3; Q543Y9; Q91W77; Q91XH9
UniProt Related Accession #
Q9EPU5
GenBank Nucleotide #
NM_178589.3
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 21
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 21
NCBI Official Symbol
Tnfrsf21
NCBI Official Synonym Symbols
DR6; TR7; R74815; AA959878
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 21
UniProt Synonym Protein Names
Death receptor 6; CD_antigen: CD358
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
Tnfrsf21
UniProt Synonym Gene Names
Dr6
UniProt Entry Name
TNR21_MOUSE
NCBI Protein Information
tumor necrosis factor receptor superfamily member 21; Death receptor 6; TNFR-related death receptor 6; TNFR-related death receptor-6

UniProt Comments for TNFRSF21

DR6: May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N- terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Associates with TRADD. Interacts with N-APP. Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.

Protein type: Receptor, cytokine; Membrane protein, integral; Apoptosis

Cellular Component: membrane; axon; integral to plasma membrane; integral to membrane; plasma membrane; intrinsic to plasma membrane

Biological Process: myelination; neuron apoptosis; adaptive immune response; negative regulation of T cell proliferation; negative regulation of myelination; apoptosis; immune system process; regulation of oligodendrocyte differentiation; B cell apoptosis; negative regulation of B cell proliferation; signal transduction; T cell receptor signaling pathway; humoral immune response
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Research Articles on TNFRSF21

1. This study demonistrated that DR6 to contribute to axonal pruning occurring during experience-dependent cortical plasticity throughout life.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with TNFRSF21 active protein

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram

Diseases associated with TNFRSF21 active protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >58 publications with TNFRSF21 and Necrosis
 Disease Models, Animal Antibodies  >8 publications with TNFRSF21 and Disease Models, Animal
 Ovarian Neoplasms Antibodies  >5 publications with TNFRSF21 and Ovarian Neoplasms
 Inflammation Antibodies  >4 publications with TNFRSF21 and Inflammation
 Neoplasms, Experimental Antibodies  >3 publications with TNFRSF21 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >2 publications with TNFRSF21 and Lung Neoplasms
 Heart Diseases Antibodies  >1 publications with TNFRSF21 and Heart Diseases
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with TNFRSF21 and Prenatal Exposure Delayed Effects
 Liver Neoplasms Antibodies  >1 publications with TNFRSF21 and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with TNFRSF21 and Cell Transformation, Neoplastic

Organs/Tissues associated with TNFRSF21 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with TNFRSF21 and Blood
 Bone Antibodies  >4 publications with TNFRSF21 and Bone
 Bone Marrow Antibodies  >3 publications with TNFRSF21 and Bone Marrow
 Brain Antibodies  >3 publications with TNFRSF21 and Brain
 Pancreas Antibodies  >2 publications with TNFRSF21 and Pancreas
 Ovary Antibodies  >2 publications with TNFRSF21 and Ovary
 Heart Antibodies  >2 publications with TNFRSF21 and Heart
 Spleen Antibodies  >2 publications with TNFRSF21 and Spleen
 Lung Antibodies  >2 publications with TNFRSF21 and Lung
 Thymus Antibodies  >2 publications with TNFRSF21 and Thymus
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