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Vinculin Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9230703

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and… More details

$455 / 0.5 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Vinculin (Vcl), Blocking Peptide
Full Product Name
Vinculin Blocking Peptide
Product Gene Name
Vcl blocking peptide
Product Synonym Names
Vinculin; Metavinculin; Vcl
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Specificity
The synthetic peptide sequence is selected from aa 903-917 of HUMAN Vcl
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
Vinculin peptide (MBS9230703) is used for blocking the activity of Vinculin antibody (MBS9217265)
Molecular Weight
116,717 Da
Cellular Location
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, focal adhesion. Note: Cytoplasmic face of adhesion plaques Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions. Co-localizes with LIMD1 in the focal adhesions (By similarity).

Other Notes

Small volumes of Vcl blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Vcl purchase

MBS9230703 is a blocking peptide targeting Vcl. Also known as Vinculin Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for Vcl. It may not necessarily be applicable to this product.

NCBI GI #
50403784
NCBI GeneID
22330
NCBI Accession #
Q64727.4
UniProt Primary Accession #
Q64727
UniProt Secondary Accession #
Q8BP32; Q8BS46; Q922C5; Q922D9
UniProt Related Accession #
Q64727
NCBI Official Full Name
Vinculin
NCBI Official Synonym Full Names
vinculin
NCBI Official Symbol
Vcl
NCBI Official Synonym Symbols
AA571387; AI462105; AW545629; 9430097D22
UniProt Protein Name
Vinculin
UniProt Synonym Protein Names
Metavinculin
Protein Family
Vinculin
UniProt Gene Name
Vcl
UniProt Entry Name
VINC_MOUSE
NCBI Protein Information
vinculin

UniProt Comments for Vcl

Vinculin: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Exhibits self-association properties. Interacts with NRAP and SORBS1. Interacts with TLN1. Interacts with SYNM. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin. Metavinculin is muscle-specific. Belongs to the vinculin/alpha-catenin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Cytoskeletal

Cellular Component: actin cytoskeleton; actin filament; adherens junction; cell-cell adherens junction; costamere; cytoplasm; fascia adherens; focal adhesion; intercellular junction; lipid raft; plasma membrane; protein complex; sarcolemma; stress fiber; Z disc

Molecular Function: alpha-catenin binding; protein binding; Rho GTPase binding; ubiquitin protein ligase binding

Biological Process: apical junction assembly; axon extension; cell adhesion; lamellipodium biogenesis; morphogenesis of an epithelium; regulation of cell migration
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Research Articles on Vcl

1. Binding of vinculin to the R1-R3 region of the talin rod is important for focal adhesion stability.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Vcl blocking peptide

 Reference Product  PubMed Publications
 Src blocking peptide  >8 publications with Vcl and Src
 Actn1 blocking peptide  >4 publications with Vcl and Actn1
 Pxn blocking peptide  >4 publications with Vcl and Pxn
 Ctnna1 blocking peptide  >3 publications with Vcl and Ctnna1
 Cdh1 blocking peptide  >2 publications with Vcl and Cdh1
 Actn2 blocking peptide  >2 publications with Vcl and Actn2
 Actn4 blocking peptide  >1 publications with Vcl and Actn4
 Tln1 blocking peptide  >1 publications with Vcl and Tln1

Pathways associated with Vcl blocking peptide

 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Diseases associated with Vcl blocking peptide

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >51 publications with Vcl and Cardiovascular Diseases
 Heart Diseases Antibodies  >22 publications with Vcl and Heart Diseases
 Nervous System Diseases Antibodies  >16 publications with Vcl and Nervous System Diseases
 Brain Diseases Antibodies  >13 publications with Vcl and Brain Diseases
 Hypertension Antibodies  >13 publications with Vcl and Hypertension
 Kidney Diseases Antibodies  >10 publications with Vcl and Kidney Diseases
 Neoplasm Metastasis Antibodies  >8 publications with Vcl and Neoplasm Metastasis
 Lung Diseases Antibodies  >8 publications with Vcl and Lung Diseases
 Inflammation Antibodies  >8 publications with Vcl and Inflammation
 Lung Neoplasms Antibodies  >7 publications with Vcl and Lung Neoplasms

Organs/Tissues associated with Vcl blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >49 publications with Vcl and Muscle
 Heart Antibodies  >28 publications with Vcl and Heart
 Testis Antibodies  >21 publications with Vcl and Testis
 Lung Antibodies  >18 publications with Vcl and Lung
 Brain Antibodies  >18 publications with Vcl and Brain
 Liver Antibodies  >14 publications with Vcl and Liver
 Kidney Antibodies  >13 publications with Vcl and Kidney
 Prostate Antibodies  >11 publications with Vcl and Prostate
 Bone Antibodies  >11 publications with Vcl and Bone
 Vagina Antibodies  >8 publications with Vcl and Vagina
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