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Vitronectin (VTN) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS141453

Introduction: Vitronectin (VTN) which is a part of the pexin family is a cell adhesion and spreading factor found in serum and tissues. VTN interacts with glycosaminoglycans and proteoglycans. VTN inhibits the membrane-damaging effect of the terminal… More details

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Product Overview

Online Datasheet in PDF
Product Name
Vitronectin (VTN), Active Protein
Full Product Name
Recombinant Human Vitronectin, Sf9
Product Gene Name
VTN active protein
Product Synonym Gene Name
Sf9
Product Synonym Names
VN; S-protein; Serum-spreading factor; V75; VTN; VTN Human, Sf9; Vitronectin Human Recombinant, Sf9
Sequence
Amino acid: ADPDQESCKG RCTEGFNVDK KCQCDELCSY YQSCCTDYTA ECKPQVTRGD VFTMPEDEYT VYDDGEEKNN ATVHEQVGGP SLTSDLQAQS KGNPEQTPVL KPEEEAPAPE VGASKPEGID SRPETLHPGR PQPPAEEELC SGKPFDAFTD LKNGSLFAFR GQYCYELDEK AVRPGYPKLI RDVWGIEGPI DAAFTRINCQ GKTYLFKGSQ YWRFEDGVLD PDYPRNISDG FDGIPDNVDA ALALPAHSYS GRERVYFFKG KQYWEYQFQH QPSQEECEGS SLSAVFEHFA MMQRDSWEDI FELLFWGRTS AGTRQPQFIS RDWHGVPGQV DAAMAGRIYI SGMAPRPSLA KKQRFRHRNR KGYRSQRGHS RGRNQNSRRP SRATWLSLFS SEESNLGANN YDDYRMDWLV PATCEPIQSV FFFSGDKYYR VNLRTRRVDT VDPPYPRSIA QYWLGCPAPG HLHHHHHH.
Host
Sf9, Insect Cells
Form/Format
Sterile filtered colorless solution.
VTN protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Purity/Purification
>90.0% as determined by SDS-PAGE.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
OMIM
193190
3D Structure
ModBase 3D Structure for P04004
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Measured by the ability of the immobilized protein to support the adhesion of B16-F10 mouse melanoma cells. The ED50 is 5ug/ml when cells are added to VTN coated plates

Product Categories/Family for VTN active protein

RECOMBINANT & NATURAL PROTEINS

Other Notes

Small volumes of VTN active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VTN purchase

MBS141453 is an active protein targeting VTN. Also known as Recombinant Human Vitronectin, Sf9. Host: Sf9, Insect Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for VTN. It may not necessarily be applicable to this product.

NCBI GI #
139653
NCBI GeneID
7448
NCBI Accession #
P04004.1
UniProt Primary Accession #
P04004
UniProt Related Accession #
P04004
NCBI Official Full Name
Vitronectin
NCBI Official Synonym Full Names
vitronectin
NCBI Official Symbol
VTN
NCBI Official Synonym Symbols
VN; V75; VNT
UniProt Protein Name
Vitronectin
UniProt Synonym Protein Names
S-protein; Serum-spreading factor; V75Cleaved into the following 3 chains:Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B
Protein Family
Vitronectin
UniProt Gene Name
VTN
UniProt Synonym Gene Names
VN
UniProt Entry Name
VTNC_HUMAN
NCBI Protein Information
vitronectin

NCBI Summary for VTN

The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]
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UniProt Comments for VTN

VTN: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 17q11

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: heparin binding; integrin binding; protein binding; extracellular matrix binding; scavenger receptor activity; polysaccharide binding

Biological Process: receptor-mediated endocytosis; extracellular matrix organization and biogenesis; positive regulation of protein binding; cell-matrix adhesion; negative regulation of blood coagulation; positive regulation of smooth muscle cell migration; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of receptor-mediated endocytosis; positive regulation of peptidyl-tyrosine phosphorylation; regulation of complement activation; cell adhesion mediated by integrin; innate immune response; immune response; cell adhesion
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Research Articles on VTN

1. Integrin alphavbeta3 is a promising biomarker alone or in combination with vitronectin for diagnosis and prognosis of early stage breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with VTN active protein

 Reference Product  PubMed Publications
 SERPINE1 active protein  >5 publications with VTN and SERPINE1
 PLAUR active protein  >3 publications with VTN and PLAUR
 ITGB3 active protein  >2 publications with VTN and ITGB3
 ITGAV active protein  >2 publications with VTN and ITGAV
 ITGB5 active protein  >1 publications with VTN and ITGB5

Pathways associated with VTN active protein

 Products by Pathway  Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram

Diseases associated with VTN active protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >5 publications with VTN and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with VTN and Carcinoma, Hepatocellular
 Disease Models, Animal Antibodies  >3 publications with VTN and Disease Models, Animal
 Heart Diseases Antibodies  >3 publications with VTN and Heart Diseases
 Fibrosis Antibodies  >2 publications with VTN and Fibrosis
 Kidney Diseases Antibodies  >2 publications with VTN and Kidney Diseases
 Weight Loss Antibodies  >2 publications with VTN and Weight Loss
 Nervous System Diseases Antibodies  >2 publications with VTN and Nervous System Diseases
 Liver Diseases Antibodies  >2 publications with VTN and Liver Diseases
 Necrosis Antibodies  >2 publications with VTN and Necrosis

Organs/Tissues associated with VTN active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with VTN and Brain
 Blood Antibodies  >12 publications with VTN and Blood
 Heart Antibodies  >6 publications with VTN and Heart
 Lung Antibodies  >4 publications with VTN and Lung
 Liver Antibodies  >4 publications with VTN and Liver
 Pancreas Antibodies  >3 publications with VTN and Pancreas
 Embryonic Tissue Antibodies  >3 publications with VTN and Embryonic Tissue
 Kidney Antibodies  >3 publications with VTN and Kidney
 Eye Antibodies  >2 publications with VTN and Eye
 Placenta Antibodies  >2 publications with VTN and Placenta
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