Multimeric Vitronectin (VTN) Porcine Protein

Name: VTN Protein; Multimeric Vitronectin; Porcine; MyBioSource
Brand: MyBioSource
SKU: MBS135803
Price: 550 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS135803

MBS135803 is a protein targeting VTN. Also known as Porcine multimeric vitronectin. Host: Porcine plasma. Prepared from fresh porcine (pig) plasma using urea as a denaturant. More details

$550 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

multimeric vitronectin (VTN), Protein

Full Product Name

Porcine multimeric vitronectin

Product Gene Name

VTN protein

Host

Porcine plasma

Form/Format

Frozen liquid

Purity/Purification

>95% by SDS-PAGE analysis

Concentration

5.0 mg/ml (lot specific)

Preparation and Storage

Store at -70 degree C. Shelf Life: 3 years from delivery

Molecular Weight

75,000 Monomer

Chromosome Location

Chromosome: 18; NC_010460.3 (5022..8400, complement). Location: chromosome: 18

3D Structure

ModBase 3D Structure for P48819

Buffer

0.05M Sodium Phosphate; 0.1M NaCl; pH 7.4

Extinction Coefficient

1.38

Product Categories/Family for VTN protein

Vitronectin; Porcine Vitronectin

Other Notes

Small volumes of VTN protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for VTN. It may not necessarily be applicable to this product.

NCBI GI #

55741847

NCBI GeneID

397192

NCBI Accession #

NP_999269.1

UniProt Primary Accession #

P48819

UniProt Related Accession #

P48819

GenBank Nucleotide #

NM_214104.1

NCBI Official Full Name

vitronectin

NCBI Official Symbol

VTN

NCBI Official Synonym Symbols

UniProt Protein Name

Vitronectin

UniProt Synonym Protein Names

S-protein; Serum-spreading factor

Protein Family

Vitronectin

UniProt Gene Name

VTN

UniProt Synonym Gene Names

UniProt Entry Name

VTNC_PIG

NCBI Protein Information

vitronectin; S-protein; serum-spreading factor

UniProt Comments for VTN

Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway

By similarity.

Subunit structure: Monomer. Interacts with SERPINE1/PAI1 and C1QBP

By similarity.

Subcellular location: Secreted › extracellular space.

Tissue specificity: Plasma.

Domain: The SMB domain mediates interaction with SERPINE1/PAI1

By similarity.

Post-translational modification: Sulfated on 2 tyrosine residues

By similarity.N- and O-glycosylated

By similarity.It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.

Sequence similarities: Contains 4 hemopexin-like domains.Contains 1 SMB (somatomedin-B) domain.

Research Articles on VTN

1. for intact vitronectin the effect of the heparin-binding domain predominates with respect to the signaling events that occur following ligand binding to the alphaVbeta3 integrin

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with VTN protein

Products by Pathway	Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
Proteoglycans In Cancer Pathway antibodies	Proteoglycans In Cancer Pathway Diagram
Proteoglycans In Cancer Pathway antibodies	Proteoglycans In Cancer Pathway Diagram

Diseases associated with VTN protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>3 publications with VTN and Cardiovascular Diseases
Kidney Diseases Antibodies	>2 publications with VTN and Kidney Diseases
Heart Diseases Antibodies	>2 publications with VTN and Heart Diseases
Drug Toxicity Antibodies	>2 publications with VTN and Drug Toxicity
Weight Loss Antibodies	>2 publications with VTN and Weight Loss
Nervous System Diseases Antibodies	>1 publications with VTN and Nervous System Diseases
Fibrosis Antibodies	>1 publications with VTN and Fibrosis
Proteinuria Antibodies	>1 publications with VTN and Proteinuria
Hypertension Antibodies	>1 publications with VTN and Hypertension
Atherosclerosis Antibodies	>1 publications with VTN and Atherosclerosis

Organs/Tissues associated with VTN protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>4 publications with VTN and Lung
Intestine Antibodies	>1 publications with VTN and Intestine
Ovary Antibodies	>1 publications with VTN and Ovary
Embryonic Tissue Antibodies	>1 publications with VTN and Embryonic Tissue
Liver Antibodies	>1 publications with VTN and Liver