Lymphotactin (XCL1) Active Protein

Name: XCL1 Active Protein; Lymphotactin; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS650875
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650875

Chemokine (C motif) ligand (XCL1) is a small cytokine belonging to the XC chemokine family that is also known as lymphotactin. It is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland… More details

$370 / 0.002 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Lymphotactin (XCL1), Active Protein

Full Product Name

Lymphotactin, Recombinant, Human (Small Inducible Cytokine Subfamily C Member 1, SCYC1, Chemokine C Motif Ligand 1, Ltn)

Product Gene Name

XCL1 active protein

Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Gln-Ser-Gl u-Val-Ser.

Host

Recombinant, human (E Coli)

Form/Format

Supplied as a lyophilized powder. No additives. Reconstitute with sterile ddH2O, 0.1% BSA or HSA to a concentration of 100ug/ml, which can then be further diluted to other aqueous solutions.

Purity/Purification

Highly Purified
98% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified. Endotoxin: < 0.1ng/ug (IEU/ug)

Preparation and Storage

Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile ddH2O, 0.1% BSA or HSA, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

10007D

Chromosome Location

Chromosome: 1; NC_000001.10 (168545856..168551315). Location: 1q23

OMIM

600250

3D Structure

ModBase 3D Structure for P47992

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Lymphotactin is fully biologically active when compared to standard. The Biological activity is calculated by its ability to chemoattract human T cells at 10.0-100.0ng/ml..

Protein Content

Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280nm.
2. Analysis by RP-HPLC, using a calibrated solution of Lymphotactin as a Reference Standard.

Product Categories/Family for XCL1 active protein

Growth Factors; Cytokines; Growth Factors-Lymphotactin

Other Notes

Small volumes of XCL1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for XCL1 purchase

MBS650875 is an active protein targeting XCL1. Also known as Lymphotactin, Recombinant, Human (Small Inducible Cytokine Subfamily C Member 1, SCYC1, Chemokine C Motif Ligand 1, Ltn). Host: Recombinant, human (E Coli).

Additional Details

NCBI/Uniprot data below describe general gene information for XCL1. It may not necessarily be applicable to this product.

NCBI GI #

4506853

NCBI GeneID

6375

NCBI Accession #

NP_002986.1

UniProt Primary Accession #

P47992

UniProt Secondary Accession #

Q52MA8

UniProt Related Accession #

P47992

GenBank Nucleotide #

NM_002995.2

NCBI Official Full Name

lymphotactin

NCBI Official Synonym Full Names

chemokine (C motif) ligand 1

NCBI Official Symbol

XCL1

NCBI Official Synonym Symbols

LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a

UniProt Protein Name

Lymphotactin

UniProt Synonym Protein Names

ATAC; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; SCM-1-alpha; Small-inducible cytokine C1; XC chemokine ligand 1

Protein Family

Lymphotactin

UniProt Gene Name

XCL1

UniProt Synonym Gene Names

LTN; SCYC1

UniProt Entry Name

XCL1_HUMAN

NCBI Protein Information

lymphotactin; SCM-1-alpha; lymphotaxin; cytokine SCM-1; OTTHUMP00000032498; c motif chemokine 1; XC chemokine ligand 1; single cysteine motif 1a; small-inducible cytokine C1; small inducible cytokine subfamily C, member 1 (lymphotactin)

NCBI Summary for XCL1

This gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq]

UniProt Comments for XCL1

Function: Chemotactic activity for lymphocytes but not for monocytes or neutrophils.

Subcellular location: Secreted.

Tissue specificity: Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.

Sequence similarities: Belongs to the intercrine gamma family.

Research Articles on XCL1

1. The expression patterns of XCR1 and XCL1 were conserved in human and mice blood cells, including certain dendritic cell subsets.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with XCL1 active protein

Reference Product	PubMed Publications
XCR1 active protein	>23 publications with XCL1 and XCR1

Pathways associated with XCL1 active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with XCL1 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>23 publications with XCL1 and Inflammation
Neoplasms, Experimental Antibodies	>14 publications with XCL1 and Neoplasms, Experimental
Necrosis Antibodies	>13 publications with XCL1 and Necrosis
Respiratory Tract Diseases Antibodies	>12 publications with XCL1 and Respiratory Tract Diseases
Hypersensitivity Antibodies	>10 publications with XCL1 and Hypersensitivity
Eye Diseases Antibodies	>4 publications with XCL1 and Eye Diseases
Multiple Myeloma Antibodies	>4 publications with XCL1 and Multiple Myeloma
Adenocarcinoma Antibodies	>3 publications with XCL1 and Adenocarcinoma
Kidney Diseases Antibodies	>3 publications with XCL1 and Kidney Diseases
Carcinoma, Squamous Cell Antibodies	>3 publications with XCL1 and Carcinoma, Squamous Cell

Organs/Tissues associated with XCL1 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>124 publications with XCL1 and Blood
Lung Antibodies	>14 publications with XCL1 and Lung
Liver Antibodies	>2 publications with XCL1 and Liver
Prostate Antibodies	>1 publications with XCL1 and Prostate