LRP1 Antibody – Rabbit Polyclonal

LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung.

Protein type: Motility/polarity/chemotaxis; Cell surface; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: focal adhesion; cell soma; clathrin-coated vesicle; lysosomal membrane; integral to plasma membrane; dendrite; cytoplasm; plasma membrane; nucleolus; coated pit; endosome; receptor complex

Molecular Function: protein binding; lipoprotein transporter activity; protease binding; protein complex binding; apolipoprotein binding; calcium ion binding; receptor activity

Biological Process: positive regulation of protein transport; receptor-mediated endocytosis; cell proliferation; positive regulation of lipid transport; cholesterol metabolic process; phototransduction, visible light; regulation of phospholipase A2 activity; negative regulation of Wnt receptor signaling pathway; lipoprotein transport; regulation of actin cytoskeleton organization and biogenesis; protein kinase C activation; lipoprotein metabolic process; negative regulation of neuron apoptosis; negative regulation of smooth muscle cell migration; retinoid metabolic process; regulation of cholesterol transport; apoptotic cell clearance; aging