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Unconventional Myosin-Xviiia (MYO18A) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1418864

MBS1418864 is a recombinant protein targeting MYO18A. Also known as Recombinant Human Unconventional myosin-XVIIIa (MYO18A) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Unconventional myosin-XVIIIa (MYO18A), Recombinant Protein
Full Product Name
Recombinant Human Unconventional myosin-XVIIIa (MYO18A) , partial
Product Gene Name
MYO18A recombinant protein
Product Synonym Gene Name
MYO18A
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
180,495 Da
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
609517
3D Structure
ModBase 3D Structure for Q92614
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MYO18A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MYO18A. It may not necessarily be applicable to this product.

NCBI GI #
1093953577
NCBI GeneID
399687
NCBI Accession #
NP_001333696.1
UniProt Primary Accession #
Q92614
UniProt Secondary Accession #
Q5H9U3; Q5QD01; Q5W9F9; Q5W9G1; Q8IXP8
UniProt Related Accession #
Q92614
GenBank Nucleotide #
NM_001346767.1
NCBI Official Full Name
unconventional myosin-XVIIIa isoform e
NCBI Official Synonym Full Names
myosin XVIIIA
NCBI Official Symbol
MYO18A
NCBI Official Synonym Symbols
MAJN; MYSPDZ; SPR210; SP-R210
UniProt Protein Name
Unconventional myosin-XVIIIa
UniProt Synonym Protein Names
Molecule associated with JAK3 N-terminus; MAJN; Myosin containing a PDZ domain; Surfactant protein receptor SP-R210
Protein Family
Unconventional myosin
UniProt Gene Name
MYO18A
UniProt Synonym Gene Names
; SP-R210
NCBI Protein Information
unconventional myosin-XVIIIa

NCBI Summary for MYO18A

The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016]

UniProt Comments for MYO18A

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939).
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Research Articles on MYO18A

1. Studies indicate that MYO18A is overexpressed in metastatic prostate cancer (PC-3) cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MYO18A recombinant protein

 Reference Product  PubMed Publications
 GOLPH3 recombinant protein  >8 publications with MYO18A and GOLPH3
 TIAF1 recombinant protein  >2 publications with MYO18A and TIAF1
 CDC42BPA recombinant protein  >1 publications with MYO18A and CDC42BPA

Pathways associated with MYO18A recombinant protein

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Signaling By FGFR In Disease Pathway antibodies  Signaling By FGFR In Disease Pathway Diagram
 Signaling By FGFR Mutants Pathway antibodies  Signaling By FGFR Mutants Pathway Diagram
 Signaling By FGFR1 Fusion Mutants Pathway antibodies  Signaling By FGFR1 Fusion Mutants Pathway Diagram
 Signaling By FGFR1 Mutants Pathway antibodies  Signaling By FGFR1 Mutants Pathway Diagram

Diseases associated with MYO18A recombinant protein

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2 publications with MYO18A and Carcinoma
 Breast Neoplasms Antibodies  >1 publications with MYO18A and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >1 publications with MYO18A and Ovarian Neoplasms
 Adenocarcinoma Antibodies  >1 publications with MYO18A and Adenocarcinoma
 Liver Diseases Antibodies  >1 publications with MYO18A and Liver Diseases

Organs/Tissues associated with MYO18A recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >6 publications with MYO18A and Muscle
 Bone Marrow Antibodies  >4 publications with MYO18A and Bone Marrow
 Blood Antibodies  >3 publications with MYO18A and Blood
 Spleen Antibodies  >2 publications with MYO18A and Spleen
 Lung Antibodies  >2 publications with MYO18A and Lung
 Lymph Antibodies  >1 publications with MYO18A and Lymph
 Heart Antibodies  >1 publications with MYO18A and Heart
 Vascular Antibodies  >1 publications with MYO18A and Vascular
 Embryonic Tissue Antibodies  >1 publications with MYO18A and Embryonic Tissue
 Lymph Node Antibodies  >1 publications with MYO18A and Lymph Node
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