Human NUDT2 Recombinant Protein – Cat# MBS145286

Nudix Type Motif 2 (NUDT2) Human Recombinant Protein

Name: NUDT2 Recombinant Protein; Nudix Type Motif 2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS145286
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS145286

Description: NUDT2 produced in E Coli is a single, non-glycosylated polypeptide chain containing 167 amino acids (1-147a.a.) and having a molecular mass of 19.0kDa.NUDT2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Nudix Type Motif 2 (NUDT2), Recombinant Protein

Full Product Name

Recombinant Human Nudix Type Motif 2

Product Gene Name

NUDT2 recombinant protein

Product Synonym Names

NUDT2 Human; Nudix Type Motif 2 Human Recombinant; nudix (nucleoside diphosphate linked moiety X)-type motif 2; APAH1; Diadenosine 5'; 5'''-P1; P4-tetraphosphate asymmetrical hydrolase; Diadenosine tetraphosphatase; Nucleoside diphosphate-linked moiety X motif 2; Ap4Aase; EC 3.6.1.17; MGC10404; Ap4A hydrolase 1; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical); diadenosine 5'; 5''-P1; P4-tetraphosphate pyrophosphohydrolase

Sequence

MGSSHHH HHH SSGLVPRGSH MALRACGLII FRRCLIPKVD NNAIEFLLLQ ASDGIHHWTP PKGHVEPGED DLETALRETQ EEAGIEAGQL TIIEGFKREL NYVARNKPKT VIYWLAEVKD YDVEIRLSHE HQAYRWLGLE EACQLAQFKE MKAALQEGHQ FLCSIEA

Host

E Coli

Form/Format

The NUDT2 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 1mM DTT, 0.1M NaCl and 10% glycerol.
Sterile Filtered clear solution.

Purity/Purification

Greater than 90% as determined by SDS-PAGE.

Molecular Weight

16,829 Da

OMIM

602852

3D Structure

ModBase 3D Structure for P50583

Product Categories/Family for NUDT2 recombinant protein

Enzymes; Nudix Type Motif

Other Notes

Small volumes of NUDT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NUDT2 purchase

MBS145286 is a recombinant protein targeting NUDT2. Also known as Recombinant Human Nudix Type Motif 2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NUDT2. It may not necessarily be applicable to this product.

NCBI GI #

4502125

NCBI GeneID

318

NCBI Accession #

NP_001152.1

UniProt Primary Accession #

P50583

UniProt Secondary Accession #

Q5T589; D3DRM0

UniProt Related Accession #

P50583

GenBank Nucleotide #

NM_001161.4

NCBI Official Full Name

bis(5'-nucleosyl)-tetraphosphatase

NCBI Official Synonym Full Names

nudix (nucleoside diphosphate linked moiety X)-type motif 2

NCBI Official Symbol

NUDT2

NCBI Official Synonym Symbols

APAH1

UniProt Protein Name

Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

UniProt Synonym Protein Names

Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; Ap4A hydrolase; Ap4Aase; Diadenosine tetraphosphatase; Nucleoside diphosphate-linked moiety X motif 2; Nudix motif 2

Protein Family

Nudix hydrolase

UniProt Gene Name

NUDT2

UniProt Synonym Gene Names

APAH1; Ap4A hydrolase; Ap4Aase; Diadenosine tetraphosphatase; Nudix motif 2

UniProt Entry Name

AP4A_HUMAN

NCBI Protein Information

bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Ap4A hydrolase 1; Ap4Aase; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical); diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; diadenosine 5',5''-P1,P4-tetraphosphate pyrophosphohydrolase; diadenosine tetraphosphatase; nucleoside diphosphate-linked moiety X motif 2; nudix motif 2

NCBI Summary for NUDT2

This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

UniProt Comments for NUDT2

NUDT2: Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. Belongs to the Nudix hydrolase family.

Protein type: Hydrolase; Nucleotide Metabolism - pyrimidine; Apoptosis; Nucleotide Metabolism - purine; EC 3.6.1.17

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: mitochondrion

Molecular Function: GTP binding; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

Biological Process: apoptosis; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Research Articles on NUDT2

1. This paper presents the crystal structure of wild-type and E58A mutant human Ap4A hydrolase.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NUDT2 recombinant protein

Products by Pathway	Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram

Diseases associated with NUDT2 recombinant protein

Disease Name	Pubmed Publications
Neoplasm Metastasis Antibodies	>1 publications with NUDT2 and Neoplasm Metastasis
Breast Neoplasms Antibodies	>1 publications with NUDT2 and Breast Neoplasms