ADH5: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
Protein type: Mitochondrial; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Amino Acid Metabolism - tyrosine; Energy Metabolism - methane; EC 1.1.1.284; Xenobiotic Metabolism - metabolism by cytochrome P450; Lipid Metabolism - fatty acid; EC 1.1.1.1; Oxidoreductase; Carbohydrate Metabolism - glycolysis and gluconeogenesis
Cellular Component: cytoplasm; mitochondrion; nucleus
Molecular Function: (R)-2-hydroxyglutarate dehydrogenase activity; (R)-2-hydroxyisocaproate dehydrogenase activity; 2-hydroxytetrahydrofuran dehydrogenase activity; 3-ketoglucose-reductase activity; 5-exo-hydroxycamphor dehydrogenase activity; acetoin dehydrogenase activity; alcohol dehydrogenase activity; aldo-keto reductase activity; arabinose reductase activity; C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity; D-arabinitol dehydrogenase (NADP+) activity; epoxide dehydrogenase activity; fatty acid binding; formaldehyde dehydrogenase activity; gluconate dehydrogenase activity; isocitrate dehydrogenase activity; metal ion binding; mevaldate reductase activity; oxidoreductase activity; phenylcoumaran benzylic ether reductase activity; protein homodimerization activity; S-(hydroxymethyl)glutathione dehydrogenase activity; steroid dehydrogenase activity; steroid dehydrogenase activity, acting on the CH-CH group of donors; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; xylose reductase activity; zinc ion binding
Biological Process: ethanol catabolic process; ethanol oxidation; formaldehyde catabolic process; peptidyl-cysteine S-nitrosylation; positive regulation of blood pressure; respiratory system process; response to lipopolysaccharide; response to nitrosative stress; response to redox state; retinoid metabolic process
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