Apoptosis-Stimulating of P53 Protein 2 (TP53BP2) Antibody – Rabbit Polyclonal

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

53BP2: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. Belongs to the ASPP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: cytoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: identical protein binding; NF-kappaB binding; p53 binding; protein binding; SH3 domain binding; SH3/SH2 adaptor activity

Biological Process: cell cycle; central nervous system development; embryonic development ending in birth or egg hatching; heart development; negative regulation of cell cycle; positive regulation of signal transduction; response to ionizing radiation; signal transduction