Beclin 1-Associated Autophagy-Related Key Regulator (ATG14) Antibody – Rabbit Polyclonal

Barkor: Required for both basal and inducible autophagy. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Forms a complex with BECN1, PIK3C3 and PIK3R4, but not with UVRAG, nor with KIAA0226/Rubicon. UVRAG and ATG14/Barkor form mutually exclusive complexes with BECN1 through direct competition. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy. Interacts with PIK3CB. Belongs to the Barkor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy

Chromosomal Location of Human Ortholog: 14q22.3

Cellular Component: autophagic vacuole; axoneme; cytoplasm; cytosol; endoplasmic reticulum membrane; nucleus; phagocytic vesicle; pre-autophagosomal structure membrane

Molecular Function: protein binding

Biological Process: autophagic vacuole formation; cellular response to glucose starvation; cellular response to starvation; endosome to lysosome transport; macroautophagy; negative regulation of protein amino acid phosphorylation; positive regulation of autophagy; positive regulation of phosphoinositide 3-kinase activity; positive regulation of protein amino acid phosphorylation; regulation of protein amino acid phosphorylation