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DACT2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150212

MBS150212 is an antibody targeting DACT2. Also known as Dact2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Dact2, Polyclonal Antibody
Full Product Name
Dact2 Antibody
Product Gene Name
anti-DACT2 antibody
Product Synonym Names
Dact2; DPR2; DAPPER2; C6orf116; bA503C24.7; PP13671; Dapper homolog 2; Dapper antagonist of catenin 2; dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid ; Dact2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purity/Purification
Dact2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
Dact2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
Dact2 peptide (MBS152860) is used for blocking the activity of Dact2 antibody (MBS150212)
OMIM
608966
3D Structure
ModBase 3D Structure for Q5SW24
Immunogen
Dact2 antibody was raised against a 12 amino acid synthetic peptide from near the amino terminus of human DACT2.
Applications Tested/Suitable for anti-DACT2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-p), Immunofluorescence (IF)
Application Notes for anti-DACT2 antibody
Optimal dilutions/concentrations should be determined by the researcher. The information provided is a guideline for product use. This product is for research only.

Western Blot (WB) of anti-DACT2 antibody

Western blot analysis of Dact2 in SK-N-SH cell lysate with Dact2 antibody at 1 μg/mL.
Rabbit Anti-DACT2 Polyclonal Antibody – Cat# MBS150212

Immunohistochemistry (IHC) of anti-DACT2 antibody

Immunohistochemistry of Dact2 in human brain tissue with Dact2 antibody at 2.5 μg/mL.
Rabbit Anti-DACT2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150212

Immunofluorescence (IF) of anti-DACT2 antibody

Immunofluorescence of Dact2 in Human Brain cells with Dact2 antibody at 20 μg/mL.
Rabbit Anti-DACT2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150212

Other Notes

Small volumes of anti-DACT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DACT2. It may not necessarily be applicable to this product.

NCBI GI #
163965434
NCBI GeneID
168002
NCBI Accession #
NP_999627
UniProt Primary Accession #
Q5SW24
UniProt Secondary Accession #
Q2NKJ2; Q569G0; Q8WYW2
UniProt Related Accession #
Q5SW24
GenBank Nucleotide #
NM_214462.4
NCBI Official Full Name
dapper homolog 2 isoform a
NCBI Official Synonym Full Names
dishevelled-binding antagonist of beta-catenin 2
NCBI Official Symbol
DACT2
NCBI Official Synonym Symbols
DPR2; DAPPER2; C6orf116; bA503C24.7
UniProt Protein Name
Dapper homolog 2
UniProt Synonym Protein Names
Dapper antagonist of catenin 2
Protein Family
Dapper
UniProt Gene Name
DACT2
UniProt Synonym Gene Names
C6orf116
UniProt Entry Name
DACT2_HUMAN
NCBI Protein Information
dapper homolog 2; dapper antagonist of catenin 2; dapper homolog 2, antagonist of beta-catenin; dapper, antagonist of beta-catenin, homolog 2

UniProt Comments for DACT2

DACT2: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling. Belongs to the dapper family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: mitochondrion

Molecular Function: protein kinase C binding; protein kinase A binding; beta-catenin binding; transcription factor binding

Biological Process: skin development; hemopoietic progenitor cell differentiation; negative regulation of cell adhesion
Show more

Research Articles on DACT2

1. Loss of DACT2 expression is associated with esophageal squamous cell carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DACT2 antibody

 Reference Product  PubMed Publications
 PRICKLE2 antibody  >2 publications with DACT2 and PRICKLE2

Pathways associated with anti-DACT2 antibody

 Products by Pathway  Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram

Diseases associated with anti-DACT2 antibody

 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >4 publications with DACT2 and Carcinoma, Hepatocellular
 Lung Neoplasms Antibodies  >2 publications with DACT2 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with DACT2 and Neoplasm Metastasis
 Kidney Diseases Antibodies  >1 publications with DACT2 and Kidney Diseases
 Liver Diseases Antibodies  >1 publications with DACT2 and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with DACT2 and Liver Neoplasms

Organs/Tissues associated with anti-DACT2 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >4 publications with DACT2 and Embryonic Tissue
 Eye Antibodies  >1 publications with DACT2 and Eye
 Placenta Antibodies  >1 publications with DACT2 and Placenta
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