ANKLE2 Antibody – Chicken Polyclonal

This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. [provided by RefSeq, Mar 2014]

ANKLE2: Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Belongs to the ANKLE2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24.33

Cellular Component: endoplasmic reticulum membrane; membrane; integral to endoplasmic reticulum membrane

Molecular Function: protein binding; protein phosphatase 2A binding; protein phosphatase type 2A regulator activity

Biological Process: mitosis; mitotic nuclear envelope reassembly; cell division; regulation of catalytic activity; negative regulation of phosphorylation; mitotic cell cycle; positive regulation of protein amino acid dephosphorylation