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ALOX12 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175763

Rabbit IgG polyclonal antibody for Arachidonate 12-lipoxygenase, 12S-type (ALOX12) detection. Tested with WB,IHC-P,ICC in Human.ALOX12, Arachidonate 12-lipoxygenase, is an enzyme that in humans is encoded by the ALOX12 gene. By fluorescence in situ… More details

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Product Overview

Product Name
ALOX12, Polyclonal Antibody
Full Product Name
Polyclonal Anti-ALOX12
Product Gene Name
anti-ALOX12 antibody
Product Synonym Names
Arachidonate 12-lipoxygenase; 12S-type (12S-LOX/12S-lipoxygenase); arachidonate 12-lipoxygenase; Platelet-type lipoxygenase 12
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Specificity
Human. No cross reactivity with other proteins.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
75,694 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (6899384..6914055). Location: 17p13.1
OMIM
152391
3D Structure
ModBase 3D Structure for P18054
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminal of human ALOX12 (588-604aa,RNEQLDWPYEYLKPS).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-ALOX12 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

Testing Data of anti-ALOX12 antibody

Rabbit Anti-ALOX12 Polyclonal Antibody – Cat# MBS175763

Immunohistochemistry (IHC) #2 of anti-ALOX12 antibody

Rabbit Anti-ALOX12 Polyclonal Antibody, Immunohistochemistry (IHC) #2 – Cat# MBS175763

Product References and Citations for anti-ALOX12 antibody

1. Funk, C. D., Furci, L., FitzGerald, G. A.Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.Proc. Nat. Acad. Sci. 87: 5638-5642, 1990.
2. Natarajan, R., Esworthy, R., Bai, W., Gu, J.-L., Wilczynski, S., Nadler, J.Increased 12-lipoxygenase expression in breast cancer tissues and cells. Regulation by epidermal growth factor.J. Clin. Endocr. Metab. 82: 1790-1798, 1997.
3. Yoshimoto, T., Arakawa, T., Hada, T., Yamamoto, S., Takahashi, E.Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene.J. Biol. Chem. 267: 24805-24809, 1992.

Other Notes

Small volumes of anti-ALOX12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALOX12 purchase

MBS175763 is an antibody targeting ALOX12. Also known as Polyclonal Anti-ALOX12. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALOX12. It may not necessarily be applicable to this product.

NCBI GI #
154426292
NCBI GeneID
239
NCBI Accession #
NP_000688.2
UniProt Primary Accession #
P18054
UniProt Secondary Accession #
O95569; Q6ISF8; Q9UQM4
UniProt Related Accession #
P18054
GenBank Nucleotide #
NM_000697.2
NCBI Official Full Name
arachidonate 12-lipoxygenase, 12S-type
NCBI Official Synonym Full Names
arachidonate 12-lipoxygenase
NCBI Official Symbol
ALOX12
NCBI Official Synonym Symbols
LOG12; 12-LOX; 12S-LOX
UniProt Protein Name
Arachidonate 12-lipoxygenase, 12S-type
UniProt Synonym Protein Names
Platelet-type lipoxygenase 12
Protein Family
Arachidonate 12-lipoxygenase
UniProt Gene Name
ALOX12
UniProt Synonym Gene Names
LOG12; 12S-LOX
UniProt Entry Name
LOX12_HUMAN
NCBI Protein Information
arachidonate 12-lipoxygenase, 12S-type; platelet 12-LOX; 12S-lipoxygenase; platelet-type 12-lipoxygenase; platelet-type lipoxygenase 12

UniProt Comments for ALOX12

ALOX12: Oxygenase and 14,15-leukotriene A4 synthase activity. Belongs to the lipoxygenase family.

Protein type: Lipid Metabolism - arachidonic acid; EC 1.13.11.31; Apoptosis; Oxidoreductase

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: membrane; cytoplasm; cytosol; sarcolemma

Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; protein binding; hepoxilin A3 synthase activity; arachidonate 12-lipoxygenase activity; lipoxygenase activity; hepoxilin-epoxide hydrolase activity; iron ion binding

Biological Process: positive regulation of cell adhesion; positive regulation of smooth muscle cell proliferation; linoleic acid metabolic process; positive regulation of caspase activity; positive regulation of vasodilation; positive regulation of cell growth; positive regulation of angiogenesis; positive regulation of endothelial cell differentiation; positive regulation of mitochondrial depolarization; lipoxygenase pathway; positive regulation of cell proliferation; arachidonic acid metabolic process; fatty acid oxidation; hepoxilin biosynthetic process; cell motility; superoxide release; hepoxilin metabolic process; positive regulation of cell migration; aging; negative regulation of apoptosis
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Research Articles on ALOX12

1. increased 15-LOX-1 and decreased 5- and 12-LOX levels at the onset of kidney cancer reversing with the progressing stage of the disease or the grade of tumor

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALOX12 antibody

 Reference Product  PubMed Publications
 PTGS2 antibody  >7 publications with ALOX12 and PTGS2
 PTGS1 antibody  >5 publications with ALOX12 and PTGS1

Pathways associated with anti-ALOX12 antibody

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram
 Synthesis Of 12-eicosatetraenoic Acid Derivatives Pathway antibodies  Synthesis Of 12-eicosatetraenoic Acid Derivatives Pathway Diagram
 Synthesis Of Hepoxilins (HX) And Trioxilins (TrX) Pathway antibodies  Synthesis Of Hepoxilins (HX) And Trioxilins (TrX) Pathway Diagram
 Synthesis Of Lipoxins (LX) Pathway antibodies  Synthesis Of Lipoxins (LX) Pathway Diagram

Diseases associated with anti-ALOX12 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >11 publications with ALOX12 and Cardiovascular Diseases
 Inflammation Antibodies  >11 publications with ALOX12 and Inflammation
 Neoplasms Antibodies  >9 publications with ALOX12 and Neoplasms
 Nervous System Diseases Antibodies  >6 publications with ALOX12 and Nervous System Diseases
 Skin Diseases Antibodies  >5 publications with ALOX12 and Skin Diseases
 Leukemia Antibodies  >4 publications with ALOX12 and Leukemia
 Brain Diseases Antibodies  >3 publications with ALOX12 and Brain Diseases
 Hypertension Antibodies  >3 publications with ALOX12 and Hypertension
 Lung Diseases Antibodies  >2 publications with ALOX12 and Lung Diseases
 Drug Toxicity Antibodies  >2 publications with ALOX12 and Drug Toxicity

Organs/Tissues associated with anti-ALOX12 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >5 publications with ALOX12 and Skin
 Muscle Antibodies  >1 publications with ALOX12 and Muscle
 Ovary Antibodies  >1 publications with ALOX12 and Ovary
 Connective Tissue Antibodies  >1 publications with ALOX12 and Connective Tissue
 Lung Antibodies  >1 publications with ALOX12 and Lung
 Embryonic Tissue Antibodies  >1 publications with ALOX12 and Embryonic Tissue
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