OGG1 Recombinant Protein

OGG1, also known as 8-oxoguanine glycosylase, is a DNA glycosylase enzyme involved in base excision repair. This protein is the primary enzyme responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG), a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen species (ROS). It has a beta lyase activity that nicks DNA 3' to the lesion. Recombinant human OGG1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.

Seeberg E., et al. (2002). Nucleic Acids Res. 30 (11):2349-57.; Hodges NJ., et al (2010). DNA Repair (Amst). 9 (2):144-52.;

Small volumes of OGG1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Molecular biology experiments require recombinant enzymes frequently. N - glycosylase DNA lyase - aka oxoguanine DNA, OGG1 human or 8 oxoguanine DNA glycosylase - is a highly purified and HIS tagged protein available to repair your DNA during cloning or UV exposure ensuring experimental fidelity. This Abnova Corporation human gene and protein product, with base excision repair capabilities, has been SDS page purified from E coli expression systems and is widely cited in publications. Human recombinant protein may also be used to generate specific species human rabbit polyclonal antibodies or anti human mouse monoclonal antibody products. The lyase activity is well known for detecting splice variants. Compare our economical 100-500ug protein h00004968 p01 OGG1 recombinant proteins to another related corporation select OGG1 recombinant protein and the value will score points. View all our cell OGG products: ELISA kits and rabbit polyclonal species to pre design your next experiment.