Mitogen Activated Protein Kinase Kinase 1 (MAP2K1) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]

MEK1: a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf, Mos and Cot kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK1 and ERK2. An essential component of MAP kinase signal transduction pathways involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: cytosol; early endosome; endoplasmic reticulum; extracellular exosome; focal adhesion; Golgi apparatus; late endosome; microtubule organizing center; mitochondrion; nucleus; plasma membrane

Molecular Function: ATP binding; MAP kinase kinase activity; protein binding; protein C-terminus binding; protein kinase activity; protein N-terminus binding; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; signal transducer, downstream of receptor, with protein tyrosine phosphatase activity

Biological Process: activation of MAPK activity; Bergmann glial cell differentiation; cell cycle arrest; cell motility; cellular senescence; cerebellar cortex formation; chemotaxis; ERK1 and ERK2 cascade; heart development; keratinocyte differentiation; MAPK cascade; negative regulation of cell proliferation; negative regulation of gene expression; neuron differentiation; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of axonogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of protein serine/threonine kinase activity; positive regulation of transcription, DNA-templated; protein amino acid phosphorylation; regulation of apoptosis; regulation of axon regeneration; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of mitotic cell cycle; regulation of stress-activated MAPK cascade; signal transduction; thymus development; thyroid gland development

Disease: Cardiofaciocutaneous Syndrome 3; Noonan Syndrome 1