ATG7 Antibody – Rabbit Polyclonal

ATG7: Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3. Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. Belongs to the ATG7 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Autophagy

Cellular Component: cytoplasm; axoneme; cytosol

Molecular Function: protein binding; protein homodimerization activity; small protein activating enzyme activity; APG8 activating enzyme activity; APG12 activating enzyme activity; transcription factor binding

Biological Process: positive regulation of apoptosis; macroautophagy; regulation of protein ubiquitination; pyramidal neuron development; adult walking behavior; post-embryonic development; protein transport; cardiac muscle cell development; transport; protein amino acid lipidation; protein catabolic process; neurite development; positive regulation of autophagy; autophagic vacuole formation; amino acid metabolic process; mitochondrion organization and biogenesis; central nervous system neuron axonogenesis; organelle organization and biogenesis; cerebellar Purkinje cell layer development; C-terminal protein lipidation; cellular response to starvation; liver development; neurological system process; cellular response to nitrogen starvation; response to starvation; protein modification by small protein conjugation; positive regulation of protein catabolic process; positive regulation of protein modification process; mitochondrion degradation; autophagy; cerebral cortex development; positive regulation of macroautophagy; negative regulation of apoptosis