Goat Anti-SORBS1 Polyclonal Antibody – Cat# MBS241656

Anti-SORBS1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

SORBS1 Antibody – Goat Polyclonal

Name: SORBS1 Antibody; Polyclonal; Goat; Human/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS241656
Price: 625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS241656

MBS241656 is an antibody targeting SORBS1. Also known as Goat Polyclonal to Human SORBS1 / Ponsin. Reactive in Gibbon, Dog, Gorilla, Horse, Human, MonkeyPredicted Reactivity: Rat (at least 90% immunogen sequence identity). Host: Goat. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

SORBS1 / Ponsin, Polyclonal Antibody

Full Product Name

Goat Polyclonal to Human SORBS1 / Ponsin

Product Gene Name

anti-SORBS1 antibody

Product Synonym Names

Anti-SORBS1 / Ponsin Antibody (Internal) IHC-plus; SORBS1; C-Cbl associated protein; C-Cbl-associated protein; CAP; FLAF2; KIAA0894; KIAA1296; R85FL; SH3 domain protein 5; SH3-domain protein 5 (ponsin); SH3P12; SORB1; Fas-ligand associated factor 2; Ponsin; SH3D5; Human SORBS1; Ponsin

Clonality

Polyclonal

Host

Goat

Species Reactivity

Gibbon, Dog, Gorilla, Horse, Human, Monkey
Predicted Reactivity: Rat (at least 90% immunogen sequence identity)

Form/Format

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

Purity/Purification

Immunoaffinity Purified

Concentration

0.5 mg/ml (lot specific)

Specificity

Human SORBS1. This antibody is expected to recognise all 7 reported isoforms (NP_006425.2, NP_056200.1, NP_001030126.1, NP_001030127.1, NP_001030128.1, NP_079267.1 and NP_001030129.1).

Preparation and Storage

Store at -20 degree C. Minimize freezing and thawing.

Molecular Weight

143,741 Da

OMIM

605264

3D Structure

ModBase 3D Structure for Q9BX66

Target Species

Human

Immunogen Description

Synthetic peptide C-SPKSEDDDSDLYSP from an internal region of human SORBS1 (NP_006425.2; NP_056200.1; NP_001030126.1; NP_001030127.1; NP_001030128.1; NP_079267.1; NP_001030129.1).

Immunogen Type

Synthetic peptide

Immunogen

SORBS1 / Ponsin antibody was raised against synthetic peptide C-SPKSEDDDSDLYSP from an internal region of human SORBS1 (NP_006425.2; NP_056200.1; NP_001030126.1; NP_001030127.1; NP_001030128.1; NP_079267.1; NP_001030129.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Dog, Elephant, Horse (100%); Rat, Opossum (93%); Mouse (86%).

Antigen Modification

Internal

Applications Tested/Suitable for anti-SORBS1 antibody

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

Application Notes for anti-SORBS1 antibody

ELISA (1:2000), IHC-P (5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Other Notes

Small volumes of anti-SORBS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SORBS1. It may not necessarily be applicable to this product.

NCBI GI #

7661700

NCBI GeneID

10580

NCBI Accession #

NP_056200.1

UniProt Primary Accession #

Q9BX66

UniProt Secondary Accession #

O43857; Q5T923; Q5T924; Q5T927; Q5T928; A0AED4; A6NEK3; A6NID8; A6NJS4; A7MD40; D3DR42

UniProt Related Accession #

Q9BX66

GenBank Nucleotide #

NM_015385.3

NCBI Official Full Name

sorbin and SH3 domain-containing protein 1 isoform 2

NCBI Official Synonym Full Names

sorbin and SH3 domain containing 1

NCBI Official Symbol

SORBS1

NCBI Official Synonym Symbols

CAP; FLAF2; R85FL; SH3D5; SORB1; SH3P12

UniProt Protein Name

Sorbin and SH3 domain-containing protein 1

UniProt Synonym Protein Names

Ponsin; SH3 domain protein 5; SH3P12; c-Cbl-associated protein; CAP

Protein Family

Sorbin and SH3 domain-containing protein

UniProt Gene Name

SORBS1

UniProt Synonym Gene Names

CAP

UniProt Entry Name

SRBS1_HUMAN

NCBI Protein Information

sorbin and SH3 domain-containing protein 1; SORBS1; ponsin; SH3 domain protein 5; c-Cbl associated protein; Fas-ligand associated factor 2

NCBI Summary for SORBS1

This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

UniProt Comments for SORBS1

SORBS1: Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions. 12 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: centrosome; nuclear matrix; focal adhesion; zonula adherens; cytosol; cell-substrate adherens junction; lipid raft; nucleoplasm; cell-cell adherens junction; cytoplasm; stress fiber; plasma membrane; nucleus

Molecular Function: protein binding; SH3/SH2 adaptor activity; cytoskeletal protein binding; actin binding; protein kinase binding; insulin receptor binding

Biological Process: focal adhesion formation; positive regulation of glucose import; positive regulation of signal transduction; muscle contraction; cellular response to insulin stimulus; cell-matrix adhesion; positive regulation of glycogen biosynthetic process; stress fiber formation; insulin receptor signaling pathway; positive regulation of lipid biosynthetic process; glucose transport

Research Articles on SORBS1

1. Sequestration of the ponsin splice variant R85FL by the polyglutamine-expanded Atx7 in cell is mediated by the specific SH3C-PRR interaction, which is implicated in the pathogenesis of spinocerebellar ataxia 7.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SORBS1 antibody

Products by Pathway	Pathway Diagram
Adherens Junction Pathway antibodies	Adherens Junction Pathway Diagram
Adherens Junction Pathway antibodies	Adherens Junction Pathway Diagram
Insulin Pathway antibodies	Insulin Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Integrin-mediated Cell Adhesion Pathway antibodies	Integrin-mediated Cell Adhesion Pathway Diagram
Muscle Contraction Pathway antibodies	Muscle Contraction Pathway Diagram
PPAR Signaling Pathway antibodies	PPAR Signaling Pathway Diagram
PPAR Signaling Pathway antibodies	PPAR Signaling Pathway Diagram

Diseases associated with anti-SORBS1 antibody

Disease Name	Pubmed Publications
Insulin Resistance Antibodies	>9 publications with SORBS1 and Insulin Resistance
Cardiovascular Diseases Antibodies	>4 publications with SORBS1 and Cardiovascular Diseases
Inflammation Antibodies	>4 publications with SORBS1 and Inflammation
Carcinoma Antibodies	>3 publications with SORBS1 and Carcinoma
Adenocarcinoma Antibodies	>1 publications with SORBS1 and Adenocarcinoma
Heart Diseases Antibodies	>1 publications with SORBS1 and Heart Diseases
Nervous System Diseases Antibodies	>1 publications with SORBS1 and Nervous System Diseases
Liver Diseases Antibodies	>1 publications with SORBS1 and Liver Diseases
Neoplasms, Experimental Antibodies	>1 publications with SORBS1 and Neoplasms, Experimental
Breast Neoplasms Antibodies	>1 publications with SORBS1 and Breast Neoplasms

Organs/Tissues associated with anti-SORBS1 antibody

Organ/Tissue Name	Pubmed Publications
Adipose Tissue Antibodies	>9 publications with SORBS1 and Adipose Tissue
Muscle Antibodies	>7 publications with SORBS1 and Muscle
Connective Tissue Antibodies	>6 publications with SORBS1 and Connective Tissue
Heart Antibodies	>4 publications with SORBS1 and Heart
Liver Antibodies	>3 publications with SORBS1 and Liver
Bone Antibodies	>2 publications with SORBS1 and Bone
Ovary Antibodies	>2 publications with SORBS1 and Ovary
Nerve Antibodies	>1 publications with SORBS1 and Nerve
Vascular Antibodies	>1 publications with SORBS1 and Vascular
Embryonic Tissue Antibodies	>1 publications with SORBS1 and Embryonic Tissue