APBA1 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]

APBA1: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q21.12

Cellular Component: Golgi apparatus; synaptic vesicle; protein complex; perinuclear region of cytoplasm; plasma membrane; nucleus

Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; beta-amyloid binding; protein complex binding; PDZ domain binding

Biological Process: synaptic transmission; intracellular protein transport; nervous system development; glutamate secretion; in utero embryonic development; regulation of gene expression; multicellular organism growth; gamma-aminobutyric acid secretion; axon cargo transport; locomotory behavior; protein complex assembly; cell adhesion