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OASIS Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244171

MBS244171 is an antibody targeting OASIS. Also known as Goat Polyclonal to Human OASIS / CREB3L1. Reactive in Gorilla, Human, Monkey. Host: Goat. More details

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Product Overview

Product Name
OASIS / CREB3L1, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human OASIS / CREB3L1
Product Gene Name
anti-OASIS antibody
Product Synonym Gene Name
CREB3L1
Product Synonym Names
Anti-OASIS / CREB3L1 Antibody (C-Terminus) IHC-plus; CREB3L1; BBF-2 homolog; OASIS; Human OASIS; CREB3L1
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gorilla, Human, Monkey
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human CREB3L1.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
47,783 Da
3D Structure
ModBase 3D Structure for Q96BA8
Target Species
Human
Immunogen Description
Synthetic peptide C-DFSHSKEWFHDRD from the C-terminus of human CREB3L1 (NP_443086.1). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%); Rat, Hamster, Elephant, Bovine, Bat, Pig (85%).
Immunogen Type
Synthetic peptide
Immunogen
OASIS / CREB3L1 antibody was raised against synthetic peptide C-DFSHSKEWFHDRD from the C-terminus of human CREB3L1 (NP_443086.1). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%); Rat, Hamster, Elephant, Bovine, Bat, Pig (85%).
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-OASIS antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-OASIS antibody
ELISA (1:32000), IHC-P (3.75 ug/ml), WB (1 - 3 ug/ml)

Immunohistochemistry (IHC) of anti-OASIS antibody

Anti-CREB3L1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-OASIS Polyclonal Antibody – Cat# MBS244171

Immunohistochemistry (IHC) of anti-OASIS antibody

Anti-CREB3L1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-OASIS Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244171

Western Blot (WB) of anti-OASIS antibody

Approx. 60 kD band observed in lysates of cell line A549 (calculated MW of 57 kD according to NP_443086.1).
Goat Anti-OASIS Polyclonal Antibody, Western Blot (WB) – Cat# MBS244171

Other Notes

Small volumes of anti-OASIS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for OASIS. It may not necessarily be applicable to this product.

NCBI GI #
16418355
NCBI GeneID
90993
NCBI Accession #
NP_443086.1
UniProt Primary Accession #
Q96BA8
UniProt Secondary Accession #
Q8N2D5; Q96CP0
UniProt Related Accession #
Q96BA8
GenBank Nucleotide #
NM_052854.3
NCBI Official Full Name
cyclic AMP-responsive element-binding protein 3-like protein 1
NCBI Official Synonym Full Names
cAMP responsive element binding protein 3-like 1
NCBI Official Symbol
CREB3L1
NCBI Official Synonym Symbols
OASIS
UniProt Protein Name
Cyclic AMP-responsive element-binding protein 3-like protein 1
UniProt Synonym Protein Names
Old astrocyte specifically-induced substance; OASIS
UniProt Gene Name
CREB3L1
UniProt Synonym Gene Names
OASIS; cAMP-responsive element-binding protein 3-like protein 1; OASIS
UniProt Entry Name
CR3L1_HUMAN
NCBI Protein Information
cyclic AMP-responsive element-binding protein 3-like protein 1; BBF-2 homolog; old astrocyte specifically-induced substance; cAMP-responsive element-binding protein 3-like protein 1

NCBI Summary for OASIS

The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]
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UniProt Comments for OASIS

CREB3L1: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE. Belongs to the bZIP family. ATF subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transcription factor

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; nucleus

Molecular Function: sequence-specific DNA binding; chromatin binding

Biological Process: transcription, DNA-dependent; unfolded protein response; regulation of bone mineralization
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Research Articles on OASIS

1. Case Report: low-grade fibromyxoid sarcoma of the kidney found to harbor the EWSR1-CREB3L1 gene fusion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OASIS antibody

 Reference Product  PubMed Publications
 CREB3L3 antibody  >3 publications with OASIS and CREB3L3

Pathways associated with anti-OASIS antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram

Diseases associated with anti-OASIS antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >3 publications with OASIS and Disease Models, Animal
 Inflammation Antibodies  >3 publications with OASIS and Inflammation
 Neoplasm Metastasis Antibodies  >2 publications with OASIS and Neoplasm Metastasis
 Cardiovascular Diseases Antibodies  >1 publications with OASIS and Cardiovascular Diseases
 Precancerous Conditions Antibodies  >1 publications with OASIS and Precancerous Conditions
 Lung Neoplasms Antibodies  >1 publications with OASIS and Lung Neoplasms
 Kidney Diseases Antibodies  >1 publications with OASIS and Kidney Diseases
 Fibrosis Antibodies  >1 publications with OASIS and Fibrosis
 Abnormalities, Drug-Induced Antibodies  >1 publications with OASIS and Abnormalities, Drug-Induced
 Uterine Cervical Neoplasms Antibodies  >1 publications with OASIS and Uterine Cervical Neoplasms

Organs/Tissues associated with anti-OASIS antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >14 publications with OASIS and Bone
 Brain Antibodies  >8 publications with OASIS and Brain
 Connective Tissue Antibodies  >5 publications with OASIS and Connective Tissue
 Mouth Antibodies  >4 publications with OASIS and Mouth
 Embryonic Tissue Antibodies  >4 publications with OASIS and Embryonic Tissue
 Pancreas Antibodies  >4 publications with OASIS and Pancreas
 Kidney Antibodies  >2 publications with OASIS and Kidney
 Liver Antibodies  >2 publications with OASIS and Liver
 Intestine Antibodies  >2 publications with OASIS and Intestine
 Ovary Antibodies  >1 publications with OASIS and Ovary
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