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VPS45 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244402

MBS244402 is an antibody targeting VPS45. Also known as Goat Polyclonal to Human VPS45. Reactive in Bat, Gibbon, Bovine, Dog, Xenopus, Gorilla, Hamster, Horse, Human, Monkey, Pig, RabbitPredicted Reactivity: Mouse, Rat, Chicken, Zebrafish (at least 90%… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
VPS45, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human VPS45
Product Gene Name
anti-VPS45 antibody
Product Synonym Names
Anti-VPS45 Antibody (Internal) IHC-plus; VPS45; H1; H1VPS45; VPS45B; VPS54A; VSP45; VSP45A; H-vps45; HlVps45; Vacuolar protein sorting 45A; VPS45A; Human VPS45
Clonality
Polyclonal
Host
Goat
Species Reactivity
Bat, Gibbon, Bovine, Dog, Xenopus, Gorilla, Hamster, Horse, Human, Monkey, Pig, Rabbit
Predicted Reactivity: Mouse, Rat, Chicken, Zebrafish (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human VPS45.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
61,983 Da
OMIM
gene 615285
3D Structure
ModBase 3D Structure for Q9NRW7
Target Species
Human
Immunogen Description
Synthetic peptide C-FQKKKPKEQQKLES from an internal region of human VPS45 (NP_009190.2).
Immunogen Type
Synthetic peptide
Immunogen
VPS45 antibody was raised against synthetic peptide C-FQKKKPKEQQKLES from an internal region of human VPS45 (NP_009190.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Hamster, Elephant, Panda, Dog, Bovine, Bat, Horse, Rabbit, Pig, Opossum, Xenopus, Salmon, Stickleback (100%); Mouse, Rat, Turkey, Chicken, Pufferfish, Zebrafish (93%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-VPS45 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-VPS45 antibody
ELISA (1:32000), IHC-P (2.5 - 3.75 ug/ml), WB (1:32000, 0.03 - 0.1 ug/ml)

Immunohistochemistry (IHC) of anti-VPS45 antibody

Anti-VPS45 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Goat Anti-VPS45 Polyclonal Antibody – Cat# MBS244402

Western Blot (WB) of anti-VPS45 antibody

Antibody (0.03 ug/ml) staining of human placenta lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-VPS45 Polyclonal Antibody, Western Blot (WB) – Cat# MBS244402

Other Notes

Small volumes of anti-VPS45 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for VPS45. It may not necessarily be applicable to this product.

NCBI GI #
525342514
NCBI GeneID
11311
NCBI Accession #
NP_001266282.1
UniProt Primary Accession #
Q9NRW7
UniProt Secondary Accession #
Q15715; Q53FR8; Q5T4P6; Q9Y4Z6; D3DUZ9; F5H8K1
UniProt Related Accession #
Q9NRW7
GenBank Nucleotide #
NM_001279353.1
NCBI Official Full Name
vacuolar protein sorting-associated protein 45 isoform 2
NCBI Official Synonym Full Names
vacuolar protein sorting 45 homolog (S. cerevisiae)
NCBI Official Symbol
VPS45
NCBI Official Synonym Symbols
H1; SCN5; VSP45; VPS45A; VPS45B; VPS54A; VSP45A; H1VPS45
UniProt Protein Name
Vacuolar protein sorting-associated protein 45
Protein Family
Vacuolar protein sorting-associated protein
UniProt Gene Name
VPS45
UniProt Synonym Gene Names
VPS45A; VPS45B; h-VPS45; hlVps45
UniProt Entry Name
VPS45_HUMAN
NCBI Protein Information
vacuolar protein sorting-associated protein 45; hlVps45; vacuolar protein sorting 45A; leucocyte vacuolar protein sorting 45

NCBI Summary for VPS45

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
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UniProt Comments for VPS45

VPS45A: May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network. Belongs to the STXBP/unc-18/SEC1 family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 1q21.2

Cellular Component: Golgi membrane; Golgi apparatus; integral to membrane; endosome membrane

Biological Process: intracellular protein transport; blood coagulation; vesicle docking during exocytosis

Disease: Neutropenia, Severe Congenital, 5, Autosomal Recessive
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Research Articles on VPS45

1. we identified a Thr224Asn mutation in the VPS45 gene in infants from consanguineous families who suffered from life-threatening neutropenia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-VPS45 antibody

 Reference Product  PubMed Publications
 ZFYVE20 antibody  >3 publications with VPS45 and ZFYVE20

Pathways associated with anti-VPS45 antibody

 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Diseases associated with anti-VPS45 antibody

 Disease Name  Pubmed Publications
 Neutropenia, Severe Congenital, Autosomal Recessive 3 Antibodies  >3 publications with VPS45 and Neutropenia, Severe Congenital, Autosomal Recessive 3
 Fibrosis Antibodies  >1 publications with VPS45 and Fibrosis
 Disease Models, Animal Antibodies  >1 publications with VPS45 and Disease Models, Animal
 Nervous System Diseases Antibodies  >1 publications with VPS45 and Nervous System Diseases

Organs/Tissues associated with anti-VPS45 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >12 publications with VPS45 and Nerve
 Blood Antibodies  >5 publications with VPS45 and Blood
 Bone Marrow Antibodies  >3 publications with VPS45 and Bone Marrow
 Bone Antibodies  >3 publications with VPS45 and Bone
 Testis Antibodies  >3 publications with VPS45 and Testis
 Brain Antibodies  >3 publications with VPS45 and Brain
 Spleen Antibodies  >2 publications with VPS45 and Spleen
 Muscle Antibodies  >2 publications with VPS45 and Muscle
 Heart Antibodies  >1 publications with VPS45 and Heart
 Ovary Antibodies  >1 publications with VPS45 and Ovary
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