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Apolipoprotein A4 / APOA4 (APOA4) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246664

Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its… More details

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Product Overview

Product Name
Apolipoprotein A4 / APOA4, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 2D1C9] (IgG1) to Human Apolipoprotein A4 / APOA4
Product Gene Name
anti-APOA4 antibody
Product Synonym Names
Anti-Apolipoprotein A4 / APOA4 Antibody (aa21-396, clone 2D1C9) IHC-plus; APOA4; Apo-AIV; Apolipoprotein A-IV; Apolipoprotein A4; ApoA-IV; Human Apolipoprotein A4; APOA4
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2D1C9
Host
Mouse
Species Reactivity
Human
Form/Format
Ascites fluid, 0.03% sodium azide. Sourced in Ascites.
Purity/Purification
Ascites
Specificity
Human APOA4
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
Molecular Weight
45,399 Da
OMIM
107690
3D Structure
ModBase 3D Structure for P06727
Target Species
Human
Immunogen Description
Purified recombinant fragment of APOA4(aa21-396) expressed in E Coli.
Immunogen Type
Recombinant protein
Immunogen
Apolipoprotein A4 / APOA4 antibody was raised against purified recombinant fragment of APOA4(aa21-396) expressed in E Coli.
Antigen Modification
aa21-396
Applications Tested/Suitable for anti-APOA4 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-APOA4 antibody
ELISA (1:10000), IHC-P (1:200), WB (1:500 - 1:2000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-APOA4 antibody

Anti-APOA4 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Mouse Anti-APOA4 Monoclonal Antibody – Cat# MBS246664

Immunohistochemistry (IHC) of anti-APOA4 antibody

Anti-APOA4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Mouse Anti-APOA4 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246664

Western Blot (WB) of anti-APOA4 antibody

Western blot of anti-APOA4 monoclonal antibody against truncated APOA4-His recombinant protein(1), truncated APOA4(aa21-396)-hIgGFc transfected CHO-K1 cell lysate(2), human serum(3) and human plasma(4).
Mouse Anti-APOA4 Monoclonal Antibody, Western Blot (WB) – Cat# MBS246664

Other Notes

Small volumes of anti-APOA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APOA4 purchase

MBS246664 is an antibody targeting APOA4. Also known as Mouse Monoclonal [clone 2D1C9] (IgG1) to Human Apolipoprotein A4 / APOA4. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for APOA4. It may not necessarily be applicable to this product.

NCBI GI #
71773110
NCBI GeneID
337
NCBI Accession #
NP_000473.2
UniProt Primary Accession #
P06727
UniProt Secondary Accession #
Q14CW8; Q6Q787; A8MSL6
UniProt Related Accession #
P06727
GenBank Nucleotide #
NM_000482.3
NCBI Official Full Name
apolipoprotein A-IV
NCBI Official Synonym Full Names
apolipoprotein A-IV
NCBI Official Symbol
APOA4
UniProt Protein Name
Apolipoprotein A-IV
UniProt Synonym Protein Names
Apolipoprotein A4
Protein Family
Apolipoprotein
UniProt Gene Name
APOA4
UniProt Synonym Gene Names
Apo-AIV; ApoA-IV
UniProt Entry Name
APOA4_HUMAN
NCBI Protein Information
apolipoprotein A-IV; apo-AIV; apoA-IV; apolipoprotein A4

UniProt Comments for APOA4

APOA4: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. Synthesized primarily in the intestine and secreted in plasma. Belongs to the apolipoprotein A1/A4/E family.

Protein type: Secreted, signal peptide; Cell adhesion; Secreted; Endoplasmic reticulum; Lipid-binding

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: extracellular space; chylomicron; cell surface; endoplasmic reticulum lumen; early endosome; extracellular region; cytosol

Molecular Function: lipid transporter activity; antioxidant activity; protein binding; copper ion binding; protein homodimerization activity; cholesterol transporter activity; cholesterol binding; phosphatidylcholine binding; lipid binding

Biological Process: phototransduction, visible light; positive regulation of fatty acid biosynthetic process; cholesterol metabolic process; multicellular organismal lipid catabolic process; removal of superoxide radicals; lipid homeostasis; protein-lipid complex assembly; neurite regeneration; lipoprotein metabolic process; cholesterol efflux; lipid transport; cholesterol biosynthetic process; phosphatidylcholine metabolic process; cholesterol homeostasis; leukocyte adhesion; reverse cholesterol transport; innate immune response in mucosa; regulation of cholesterol absorption; phospholipid efflux; response to lipid hydroperoxide; hydrogen peroxide catabolic process; positive regulation of lipoprotein lipase activity; regulation of cholesterol transport; retinoid metabolic process
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Research Articles on APOA4

1. transcriptional regulation of apolipoprotein A-IV by the transcription factor CREBH

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-APOA4 antibody

 Reference Product  PubMed Publications
 APOC3 antibody  >42 publications with APOA4 and APOC3
 APOA1 antibody  >38 publications with APOA4 and APOA1
 LPL antibody  >14 publications with APOA4 and LPL
 APOB antibody  >13 publications with APOA4 and APOB
 APOC2 antibody  >7 publications with APOA4 and APOC2
 APOA2 antibody  >5 publications with APOA4 and APOA2
 TTR antibody  >2 publications with APOA4 and TTR
 MTTP antibody  >1 publications with APOA4 and MTTP

Pathways associated with anti-APOA4 antibody

 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram

Organs/Tissues associated with anti-APOA4 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >73 publications with APOA4 and Blood
 Liver Antibodies  >24 publications with APOA4 and Liver
 Intestine Antibodies  >8 publications with APOA4 and Intestine
 Pancreas Antibodies  >2 publications with APOA4 and Pancreas
 Stomach Antibodies  >1 publications with APOA4 and Stomach
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