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MYOD Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248172

The myoD1 gene product is involved in converting many differentiated cell types into muscle. The MyoD protein is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. MYOD1 gene is tightly linked to the… More details

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Product Overview

Online Datasheet in PDF
Product Name
MYOD / MYOD1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human MYOD / MYOD1
Product Gene Name
anti-MYOD antibody
Product Synonym Gene Name
MYOD1
Product Synonym Names
Anti-MYOD / MYOD1 Antibody (aa211-240) IHC-plus; MYOD1; BHLHc1; Myogenic differentiation 1; Myf-3; MYOD; Myogenic factor 3; PUM; MYF3; Human MYOD; MYOD1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity Purified
Specificity
Human MYOD
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
34,501 Da
OMIM
159970
3D Structure
ModBase 3D Structure for P15172
Target Species
Human
Immunogen Description
KLH-conjugated synthetic peptide from internal region of human MyoD1.
Immunogen Type
Synthetic peptide
Immunogen
MYOD / MYOD1 antibody was raised against kLH-conjugated synthetic peptide from internal region of human MyoD1.
Antigen Modification
aa211-240
Applications Tested/Suitable for anti-MYOD antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-MYOD antibody
IF (1:10 - 1:50), IHC-P (5 ug/ml), WB (1:1000)

Immunohistochemistry (IHC) of anti-MYOD antibody

Anti-MYOD / MYOD1 antibody IHC staining of human small intestine, muscularis propria. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-MYOD Polyclonal Antibody – Cat# MBS248172

Immunofluorescence (IF) of anti-MYOD antibody

Confocal immunofluorescence of MyoD1 Antibody (Center)with MDA-MB231 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).
Rabbit Anti-MYOD Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS248172

Western Blot (WB) of anti-MYOD antibody

MyoD1 Antibody (Center) Western blot of HL-60 cell line lysates (35 ug/lane). This demonstrates the MyoD1 antibody detected the MyoD1 protein (arrow).
Rabbit Anti-MYOD Polyclonal Antibody, Western Blot (WB) – Cat# MBS248172

Other Notes

Small volumes of anti-MYOD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MYOD purchase

MBS248172 is an antibody targeting MYOD. Also known as Rabbit Polyclonal to Human MYOD / MYOD1. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MYOD. It may not necessarily be applicable to this product.

NCBI GI #
23111009
NCBI GeneID
4654
NCBI Accession #
NP_002469.2
UniProt Primary Accession #
P15172
UniProt Secondary Accession #
O75321
UniProt Related Accession #
P15172
GenBank Nucleotide #
NM_002478.4
NCBI Official Full Name
myoblast determination protein 1
NCBI Official Synonym Full Names
myogenic differentiation 1
NCBI Official Symbol
MYOD1
NCBI Official Synonym Symbols
PUM; MYF3; MYOD; bHLHc1
UniProt Protein Name
Myoblast determination protein 1
UniProt Synonym Protein Names
Class C basic helix-loop-helix protein 1; bHLHc1; Myogenic factor 3; Myf-3
Protein Family
Myosin
UniProt Gene Name
MYOD1
UniProt Synonym Gene Names
BHLHC1; MYF3; MYOD; bHLHc1; Myf-3
UniProt Entry Name
MYOD1_HUMAN
NCBI Protein Information
myoblast determination protein 1; myf-3; myogenic factor 3; class C basic helix-loop-helix protein 1

NCBI Summary for MYOD

This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]
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UniProt Comments for MYOD

MyoD: a transcription factor of the basic helix-loop-helix family and the myogenic factors subfamily. Involved in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. It is involved in muscle cell differentiation, and is essential for repair of damaged tissue. It activates its own transcription which may stabilize commitment to myogenesis.

Protein type: Transcription factor; RNA splicing; DNA-binding

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: nucleoplasm; transcription factor complex; myofibril; cytoplasm; nuclear chromatin; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; chromatin DNA binding; protein heterodimerization activity; ubiquitin protein ligase binding; transcription coactivator activity; transcription factor binding; nuclear hormone receptor binding

Biological Process: transcription from RNA polymerase II promoter; muscle development; skeletal muscle development; skeletal muscle fiber adaptation; positive regulation of skeletal muscle regeneration; regulation of RNA splicing; myotube differentiation involved in skeletal muscle regeneration; muscle cell fate commitment; myotube cell development; skeletal muscle fiber development; cellular response to starvation; protein amino acid phosphorylation; positive regulation of myoblast differentiation; regulation of transcription from RNA polymerase II promoter; muscle cell differentiation; positive regulation of skeletal muscle fiber development; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; myoblast cell fate determination; regulation of alternative nuclear mRNA splicing, via spliceosome
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Research Articles on MYOD

1. MyoD was required for the induction of FGF21 gene transcription by mitochondrial dysfunction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MYOD antibody

 Reference Product  PubMed Publications
 MEF2C antibody  >20 publications with MYOD and MEF2C
 TCF3 antibody  >16 publications with MYOD and TCF3
 ID1 antibody  >8 publications with MYOD and ID1
 CDK4 antibody  >5 publications with MYOD and CDK4
 MEF2A antibody  >5 publications with MYOD and MEF2A
 HEY1 antibody  >4 publications with MYOD and HEY1
 SMARCA4 antibody  >3 publications with MYOD and SMARCA4
 CREBBP antibody  >2 publications with MYOD and CREBBP
 EP300 antibody  >2 publications with MYOD and EP300

Pathways associated with anti-MYOD antibody

 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Myogenesis Pathway antibodies  Myogenesis Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
 Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram
 Regulation Of Retinoblastoma Protein Pathway antibodies  Regulation Of Retinoblastoma Protein Pathway Diagram
 Signaling Events Mediated By HDAC Class III Pathway antibodies  Signaling Events Mediated By HDAC Class III Pathway Diagram
 MiRs In Muscle Cell Differentiation Pathway antibodies  MiRs In Muscle Cell Differentiation Pathway Diagram

Diseases associated with anti-MYOD antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >92 publications with MYOD and Nervous System Diseases
 Rhabdomyosarcoma, Embryonal Antibodies  >71 publications with MYOD and Rhabdomyosarcoma, Embryonal
 Necrosis Antibodies  >31 publications with MYOD and Necrosis
 Inflammation Antibodies  >22 publications with MYOD and Inflammation
 Muscular Atrophy Antibodies  >22 publications with MYOD and Muscular Atrophy
 Cardiovascular Diseases Antibodies  >14 publications with MYOD and Cardiovascular Diseases
 Lung Diseases Antibodies  >13 publications with MYOD and Lung Diseases
 Heart Diseases Antibodies  >13 publications with MYOD and Heart Diseases
 Lung Neoplasms Antibodies  >13 publications with MYOD and Lung Neoplasms
 Breast Neoplasms Antibodies  >12 publications with MYOD and Breast Neoplasms

Organs/Tissues associated with anti-MYOD antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >698 publications with MYOD and Muscle
 Heart Antibodies  >45 publications with MYOD and Heart
 Eye Antibodies  >12 publications with MYOD and Eye
 Lymph Antibodies  >9 publications with MYOD and Lymph
 Placenta Antibodies  >2 publications with MYOD and Placenta
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