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ADRA2C Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2574357

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic… More details

$265 / 0.06 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ADRA2C, Polyclonal Antibody
Full Product Name
ADRA2C Polyclonal Antibody
Product Gene Name
anti-ADRA2C antibody
Product Synonym Names
ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR; ADRA2C
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Purity/Purification
Affinity purification
Concentration
1mg/mL (lot specific)
Preparation and Storage
Storage: -20 degree C/One year. Avoid freeze/thaw cycles.
Molecular Weight
49,522 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (3768296..3770253). Location: 4p16
OMIM
104250
3D Structure
ModBase 3D Structure for P18825
Immunogen
Recombinant fusion protein of human ADRA2C
Research Area
Neuroscience, Signal Transduction

Product Categories/Family for anti-ADRA2C antibody

Antibodies; Primary Antibodies; Polyclonal Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ADRA2C antibody
Western Blot (WB)
Application Notes for anti-ADRA2C antibody
WB: 1:500-1:2000

Western Blot (WB) of anti-ADRA2C antibody

Western blot analysis of extracts of various cell lines using ADRA2C Polyclonal Antibody at1:1000 dilution.
Rabbit Anti-ADRA2C Polyclonal Antibody – Cat# MBS2574357

Other Notes

Small volumes of anti-ADRA2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADRA2C purchase

MBS2574357 is an antibody targeting ADRA2C. Also known as ADRA2C Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ADRA2C. It may not necessarily be applicable to this product.

NCBI GI #
71773208
NCBI GeneID
152
NCBI Accession #
NP_000674.2
UniProt Primary Accession #
P18825
UniProt Secondary Accession #
P35369; Q9HB49
UniProt Related Accession #
P18825
GenBank Nucleotide #
NM_000683.3
NCBI Official Full Name
alpha-2C adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor alpha 2C
NCBI Official Symbol
ADRA2C
NCBI Official Synonym Symbols
ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR
UniProt Protein Name
Alpha-2C adrenergic receptor
UniProt Synonym Protein Names
Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenoreceptor
Protein Family
Alpha-2C adrenergic receptor
UniProt Gene Name
ADRA2C
UniProt Synonym Gene Names
ADRA2L2; ADRA2RL2; Alpha-2C adrenoceptor; Alpha-2CAR
UniProt Entry Name
ADA2C_HUMAN
NCBI Protein Information
alpha-2C adrenergic receptor; alpha-2CAR; alpha2-AR-C4; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2C-adrenergic receptor; adrenergic, alpha-2C-, receptor; alpha-2 adrenergic receptor subtype C4

UniProt Comments for ADRA2C

ADRA2C: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p16

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; nerve terminal; endosome

Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; alpha2-adrenergic receptor activity; epinephrine binding; alpha-2A adrenergic receptor binding

Biological Process: platelet activation; G-protein coupled receptor protein signaling pathway; cell-cell signaling; activation of protein kinase B; energy reserve metabolic process; positive regulation of vasoconstriction; negative regulation of epinephrine secretion; female pregnancy; regulation of sensory perception of pain; positive regulation of neuron differentiation; blood coagulation; regulation of insulin secretion
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Research Articles on ADRA2C

1. The ADRA2A and ADRA2C polymorphisms did not contribute to an increased risk of ischemic stroke or any pathophysiological subtype

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ADRA2C antibody

 Products by Pathway  Pathway Diagram
 Adrenaline Signalling Through Alpha-2 Adrenergic Receptor Pathway antibodies  Adrenaline Signalling Through Alpha-2 Adrenergic Receptor Pathway Diagram
 Adrenoceptors Pathway antibodies  Adrenoceptors Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (z) Signalling Events Pathway antibodies  G Alpha (z) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Diseases associated with anti-ADRA2C antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >35 publications with ADRA2C and Heart Diseases
 Heart Failure Antibodies  >32 publications with ADRA2C and Heart Failure
 Nervous System Diseases Antibodies  >18 publications with ADRA2C and Nervous System Diseases
 Pain Antibodies  >13 publications with ADRA2C and Pain
 Hypertension Antibodies  >12 publications with ADRA2C and Hypertension
 Cardiomegaly Antibodies  >8 publications with ADRA2C and Cardiomegaly
 Neoplasms Antibodies  >8 publications with ADRA2C and Neoplasms
 Ventricular Dysfunction, Left Antibodies  >6 publications with ADRA2C and Ventricular Dysfunction, Left
 Anxiety Disorders Antibodies  >3 publications with ADRA2C and Anxiety Disorders
 Myocardial Ischemia Antibodies  >3 publications with ADRA2C and Myocardial Ischemia

Organs/Tissues associated with anti-ADRA2C antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >51 publications with ADRA2C and Heart
 Brain Antibodies  >44 publications with ADRA2C and Brain
 Kidney Antibodies  >15 publications with ADRA2C and Kidney
 Ovary Antibodies  >4 publications with ADRA2C and Ovary
 Eye Antibodies  >3 publications with ADRA2C and Eye
 Uterus Antibodies  >1 publications with ADRA2C and Uterus
 Pancreas Antibodies  >1 publications with ADRA2C and Pancreas
 Embryonic Tissue Antibodies  >1 publications with ADRA2C and Embryonic Tissue
 Connective Tissue Antibodies  >1 publications with ADRA2C and Connective Tissue
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