Alpha-Actinin-4 (ACTN4) ELISA Kit for Rat

ACTN4: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Defects in ACTN4 are the cause of focal segmental glomerulosclerosis type 1 (FSGS1). A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Belongs to the alpha-actinin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Cellular Component: actin cytoskeleton; brush border; cortical cytoskeleton; cytoplasm; cytosol; extracellular space; focal adhesion; intercellular junction; intracellular; neuron projection; nucleus; perinuclear region of cytoplasm; protein complex; pseudopodium; ribonucleoprotein complex; stress fiber; Z disc

Molecular Function: actin filament binding; calcium ion binding; chromatin DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; nucleoside binding; protein binding; protein complex binding; protein homodimerization activity; protein N-terminus binding; retinoic acid receptor binding

Biological Process: actin filament bundle formation; negative regulation of cell motility; positive regulation of cell migration; positive regulation of cell motility; positive regulation of pinocytosis; protein transport; regulation of apoptosis; response to hypoxia; retinoic acid receptor signaling pathway; vesicle transport along actin filament