Goat Anti-VAV2 Polyclonal Antibody – Cat# MBS421505

Staining (1.5ug/ml) of 293 lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

VAV2 Antibody – Goat Polyclonal

Name: VAV2 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS421505
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421505

MBS421505 is an antibody targeting VAV2. Also known as Goat anti-VAV2 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

VAV2, Polyclonal Antibody

Full Product Name

Goat anti-VAV2 Antibody

Product Gene Name

anti-VAV2 antibody

Product Synonym Names

VAV2; vav 2 oncogene; Oncogene VAV2; vav 2 guanine nucleotide exchange factor; Protein vav-2; oncogene VAV2; VAV2 antibody; vav 2 oncogene antibody; Oncogene VAV2 antibody; vav 2 guanine nucleotide exchange factor antibody; Protein vav-2 antibody; oncogene VAV2 antibody

Immunogen Sequence

ETEAKYYRTL EDIEC

Clonality

Polyclonal

Host

Goat

Species Reactivity

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

VAV2 peptide (MBS425097) is used for blocking the activity of VAV2 antibody (MBS421505)

Molecular Weight

97,032 Da

OMIM

600428

Immunogen

Peptide with sequence ETEAKYYRTLEDIEC, from the internal region of the protein sequence according to NP_001127870.1; NP_003362.2.

Epitope

Internal region

Note

This antobody is expected to recognise both reported isoforms (NP_001127870.1 and NP_003362.2).

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-VAV2 antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-VAV2 antibody

Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 100kDa band observed in 293 lysate (predicted MW of 100kDa according to NP_003362). Recommended for use at 1-1.5ug/ml.

Other Notes

Small volumes of anti-VAV2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for VAV2. It may not necessarily be applicable to this product.

NCBI GI #

197304715

NCBI GeneID

7410

NCBI Accession #

NP_001127870.1

NCBI Related Accession #

NP_003362.2

UniProt Secondary Accession #

Q5SYV3; Q5SYV4; Q5SYV5; Q6N012; Q6PIJ9; Q6Q317; A2RUM4; A8MQ12; B6ZDF5

UniProt Related Accession #

P52735

GenBank Nucleotide #

NM_001134398.1

NCBI Official Full Name

guanine nucleotide exchange factor VAV2 isoform 1

NCBI Official Synonym Full Names

vav guanine nucleotide exchange factor 2

NCBI Official Symbol

VAV2

NCBI Official Synonym Symbols

VAV-2

UniProt Protein Name

Guanine nucleotide exchange factor VAV2

Protein Family

Guanine nucleotide exchange factor

UniProt Gene Name

VAV2

UniProt Synonym Gene Names

VAV-2

UniProt Entry Name

VAV2_HUMAN

NCBI Protein Information

guanine nucleotide exchange factor VAV2

NCBI Summary for VAV2

VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

UniProt Comments for VAV2

VAV2: a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed in most tissues.

Protein type: Motility/polarity/chemotaxis; GEFs, Rac/Rho; GEFs

Chromosomal Location of Human Ortholog: 9q34.1

Cellular Component: cytosol; plasma membrane

Molecular Function: epidermal growth factor receptor binding; guanyl-nucleotide exchange factor activity; metal ion binding; protein binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: angiogenesis; cell migration; ephrin receptor signaling pathway; lamellipodium biogenesis; platelet activation; positive regulation of apoptosis; positive regulation of GTPase activity; positive regulation of phosphoinositide 3-kinase activity; regulation of blood coagulation; regulation of cell size; regulation of gene expression; regulation of GTPase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway

Research Articles on VAV2

1. VAV2 is required for Met signaling in the perinuclear endosome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-VAV2 antibody

Reference Product	PubMed Publications
RAC1 antibody	>83 publications with VAV2 and RAC1
RHOA antibody	>56 publications with VAV2 and RHOA
CDC42 antibody	>42 publications with VAV2 and CDC42
EGFR antibody	>14 publications with VAV2 and EGFR
SYK antibody	>11 publications with VAV2 and SYK
RHOG antibody	>6 publications with VAV2 and RHOG
CBL antibody	>4 publications with VAV2 and CBL
PTK2 antibody	>4 publications with VAV2 and PTK2
RAC3 antibody	>1 publications with VAV2 and RAC3

Pathways associated with anti-VAV2 antibody

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
BCR Signaling Pathway antibodies	BCR Signaling Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram
CDC42 Signaling Events Pathway antibodies	CDC42 Signaling Events Pathway Diagram
Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies	Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram

Diseases associated with anti-VAV2 antibody

Disease Name	Pubmed Publications
Neoplasm Invasiveness Antibodies	>11 publications with VAV2 and Neoplasm Invasiveness
Vascular Diseases Antibodies	>9 publications with VAV2 and Vascular Diseases
Lung Neoplasms Antibodies	>7 publications with VAV2 and Lung Neoplasms
Cell Transformation, Neoplastic Antibodies	>7 publications with VAV2 and Cell Transformation, Neoplastic
Neoplasms, Experimental Antibodies	>6 publications with VAV2 and Neoplasms, Experimental
Inflammation Antibodies	>5 publications with VAV2 and Inflammation
Adenocarcinoma Antibodies	>5 publications with VAV2 and Adenocarcinoma
Liver Neoplasms Antibodies	>4 publications with VAV2 and Liver Neoplasms
Carcinoma, Squamous Cell Antibodies	>3 publications with VAV2 and Carcinoma, Squamous Cell
Kidney Diseases Antibodies	>3 publications with VAV2 and Kidney Diseases

Organs/Tissues associated with anti-VAV2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>52 publications with VAV2 and Blood
Lung Antibodies	>14 publications with VAV2 and Lung
Brain Antibodies	>10 publications with VAV2 and Brain
Kidney Antibodies	>9 publications with VAV2 and Kidney
Liver Antibodies	>6 publications with VAV2 and Liver
Nerve Antibodies	>6 publications with VAV2 and Nerve
Intestine Antibodies	>4 publications with VAV2 and Intestine
Thymus Antibodies	>4 publications with VAV2 and Thymus
Skin Antibodies	>3 publications with VAV2 and Skin
Prostate Antibodies	>3 publications with VAV2 and Prostate