Mouse Anti-NCAM1 Monoclonal Antibody – Cat# MBS439343

Formalin-fixed, paraffin-embedded human Colon stained with CD56 Monoclonal Antibody (NCAM1/784)

CD56 / NCAM1 / NKH1 (NCAM1) Antibody – Mouse Monoclonal

Name: NCAM1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS439343
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439343

MBS439343 is an antibody targeting NCAM1. Also known as CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Mouse Monoclonal Antibody. Reactive in Human. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD56 / NCAM1 / NKH1, Monoclonal Antibody

Full Product Name

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Mouse Monoclonal Antibody

Product Gene Name

anti-NCAM1 antibody

Product Synonym Names

NCAM, Leu-19, NKH1, MSK39, NCAM120, NCAM140, NCAM180, Neural Cell Adhesion Molecule

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone Number

NCAM1/784

Host

Mouse

Species Reactivity

Human

Form/Format

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Specificity

This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the nodal and nasal NK/T-cell lymphomas.

Preparation and Storage

Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Molecular Weight

180; 145; 125kDa

OMIM

116930

3D Structure

ModBase 3D Structure for P13591

Cellular Localization

Cell Surface

Immunogen

Recombinant human NCAM1 protein

Hu-Chromosome Location

11q23.1

Positive Control

Cerebellum, Pancreas, Neuroblastoma

Applications Tested/Suitable for anti-NCAM1 antibody

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

Application Notes for anti-NCAM1 antibody

Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)

Product References and Citations for anti-NCAM1 antibody

Endo, C., et al. 2009. Immunocytochemical evaluation of large cell neuroendocrine carcinoma of the lung. Acta Cytol. 53: 36-40

Other Notes

Small volumes of anti-NCAM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NCAM1. It may not necessarily be applicable to this product.

NCBI GI #

94420689

NCBI GeneID

4684

NCBI Accession #

NP_000606.3

UniProt Primary Accession #

P13591

UniProt Secondary Accession #

P13592; P13593; Q05C58; Q15829; Q16180; Q16209; Q59FL7; Q86X47; Q96CJ3; A8K8T8

UniProt Related Accession #

P13591

GenBank Nucleotide #

NM_000615.6

NCBI Official Full Name

neural cell adhesion molecule 1 isoform 1

NCBI Official Synonym Full Names

neural cell adhesion molecule 1

NCBI Official Symbol

NCAM1

NCBI Official Synonym Symbols

CD56; NCAM; MSK39

UniProt Protein Name

Neural cell adhesion molecule 1

UniProt Synonym Protein Names

CD_antigen: CD56

Protein Family

Neural cell adhesion molecule

UniProt Gene Name

NCAM1

UniProt Synonym Gene Names

NCAM; N-CAM-1; NCAM-1

UniProt Entry Name

NCAM1_HUMAN

NCBI Protein Information

neural cell adhesion molecule 1

NCBI Summary for NCAM1

This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

UniProt Comments for NCAM1

NCAM1: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Membrane protein, GPI anchor; Cell adhesion

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: cell surface; cytoplasm; external side of plasma membrane; Golgi membrane; membrane; plasma membrane

Molecular Function: Ras guanyl-nucleotide exchange factor activity

Biological Process: axon guidance; MAPKKK cascade

Research Articles on NCAM1

1. CD56 marker is a useful alternative that is comparable to SSTR2A for the diagnosis of phosphaturic mesenchymal tumors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NCAM1 antibody

Reference Product	PubMed Publications
ICAM1 antibody	>130 publications with NCAM1 and ICAM1
ST8SIA2 antibody	>80 publications with NCAM1 and ST8SIA2
FYN antibody	>51 publications with NCAM1 and FYN
PTK2 antibody	>24 publications with NCAM1 and PTK2
ST8SIA4 antibody	>20 publications with NCAM1 and ST8SIA4
IL2 antibody	>18 publications with NCAM1 and IL2
SPTBN2 antibody	>1 publications with NCAM1 and SPTBN2
SPTBN1 antibody	>1 publications with NCAM1 and SPTBN1
PRNP antibody	>1 publications with NCAM1 and PRNP

Pathways associated with anti-NCAM1 antibody

Products by Pathway	Pathway Diagram
ARMS-mediated Activation Pathway antibodies	ARMS-mediated Activation Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram
Cardiac Progenitor Differentiation Pathway antibodies	Cardiac Progenitor Differentiation Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram

Diseases associated with anti-NCAM1 antibody

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>586 publications with NCAM1 and Brain Diseases
Disease Models, Animal Antibodies	>283 publications with NCAM1 and Disease Models, Animal
Necrosis Antibodies	>283 publications with NCAM1 and Necrosis
Inflammation Antibodies	>260 publications with NCAM1 and Inflammation
Lung Neoplasms Antibodies	>233 publications with NCAM1 and Lung Neoplasms
Congenital Abnormalities Antibodies	>205 publications with NCAM1 and Congenital Abnormalities
Liver Diseases Antibodies	>194 publications with NCAM1 and Liver Diseases
Neoplasm Invasiveness Antibodies	>153 publications with NCAM1 and Neoplasm Invasiveness
Neurobehavioral Manifestations Antibodies	>120 publications with NCAM1 and Neurobehavioral Manifestations
Liver Neoplasms Antibodies	>119 publications with NCAM1 and Liver Neoplasms

Organs/Tissues associated with anti-NCAM1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2875 publications with NCAM1 and Brain
Blood Antibodies	>2624 publications with NCAM1 and Blood
Nerve Antibodies	>1822 publications with NCAM1 and Nerve
Embryonic Tissue Antibodies	>857 publications with NCAM1 and Embryonic Tissue
Muscle Antibodies	>584 publications with NCAM1 and Muscle
Bone Antibodies	>550 publications with NCAM1 and Bone
Skin Antibodies	>392 publications with NCAM1 and Skin
Vascular Antibodies	>384 publications with NCAM1 and Vascular
Eye Antibodies	>349 publications with NCAM1 and Eye
Lung Antibodies	>343 publications with NCAM1 and Lung