Rabbit Anti-WWOX2 Polyclonal Antibody – Cat# MBS5400253

WWOX2 Antibody – Rabbit Polyclonal

Name: WWOX2 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS5400253
Price: 480 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5400253

Affinity Purified Abberant WW domain-containing Oxidoreductase AntibodyPutative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to… More details

$480 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

WWOX2, Polyclonal Antibody

Full Product Name

WWOX2 Antibody Affinity Purified

Product Gene Name

anti-WWOX2 antibody

Product Synonym Names

FOR; FOR II protein; FOR1; FRA16D; Fragile 16D oxido reductase; Fragile site FRA16D oxidoreductase; Putative oxidoreductase; WOX1; WW domain containing oxidoreductase; WW domain containing protein WWOX; WW domain oxidoreductase; WWOX antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Affinity Purified

Concentration

0.5-0.75 ug/ul in antibody stabilization buffer (lot specific)

Preparation and Storage

-20 degree C for long term storage

Matching Pairs

Antibody: WWOX2 (MBS5400253)
Positive Control: WWOX2 (MBS543383)

Antibody/Peptide Pairs

WWOX2 peptide (MBS544662) is used for blocking the activity of WWOX2 antibody (MBS5400253)

Molecular Weight

23,868 Da

OMIM

133239

3D Structure

ModBase 3D Structure for Q9NZC7

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on WWOX2 protein.

Expression

Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.

Molecular Function

Coenzyme binding; protein dimerization activity; cofactor binding;

Structure

Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN.

Subcellular Location

Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus

Product Categories/Family for anti-WWOX2 antibody

Primary Antibodies; Cancer Research; Invasion/microenviornment; Apoptosis; WWOX2 Antibody

Applications Tested/Suitable for anti-WWOX2 antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-WWOX2 antibody

Dot Blot: 1:10,000-1:100,000
ELISA: 1:10,000-1:100,000
Western Blot: 1:500

Other Notes

Small volumes of anti-WWOX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WWOX2 purchase

MBS5400253 is an antibody targeting WWOX2. Also known as WWOX2 Antibody Affinity Purified. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for WWOX2. It may not necessarily be applicable to this product.

NCBI GI #

15667688

NCBI Accession #

AAL05451.1

UniProt Primary Accession #

Q9NZC7

UniProt Secondary Accession #

Q5MYT5; Q96KM3; Q96RF2; Q9BTT8; Q9NPC9; Q9NRF4; Q9NRF5; Q9NRF6; Q9NRK1; Q9NZC5; A8K323

NCBI Official Full Name

aberrant WW domain-containing oxidoreductase

UniProt Protein Name

WW domain-containing oxidoreductase

UniProt Synonym Protein Names

Fragile site FRA16D oxidoreductase; Short chain dehydrogenase/reductase family 41C member 1

UniProt Gene Name

WWOX

UniProt Synonym Gene Names

FOR; SDR41C1; WOX1

UniProt Entry Name

WWOX_HUMAN

UniProt Comments for WWOX2

WWOX: an enzyme which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). Expressed at high levels in hormonally regulated tissues such as testis, ovary, and prostate. Its SRD domain suggest a role for this gene in steroid metabolism. Shown to be an essential mediator of tumor necrosis factor-alpha-induced apoptosis in the mouse. May play a similar role in the human. May function as a suppressor of tumor growth. Alternative splicing of this gene generates 7 isoforms.

Protein type: Tumor suppressor; Apoptosis; Oxidoreductase; EC 1.1.1.-

Chromosomal Location of Human Ortholog: 16q23

Cellular Component: cytoplasm; cytosol; Golgi apparatus; microvillus; mitochondrion; nucleus; plasma membrane

Molecular Function: coenzyme binding; cofactor binding; enzyme binding; oxidoreductase activity; protein binding; protein dimerization activity

Biological Process: negative regulation of Wnt receptor signaling pathway; osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; skeletal morphogenesis; steroid metabolic process; Wnt receptor signaling pathway

Disease: Epileptic Encephalopathy, Early Infantile, 28

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-WWOX2 antibody

Reference Product	PubMed Publications
TP53 antibody	>11 publications with WWOX2 and TP53
ERBB4 antibody	>10 publications with WWOX2 and ERBB4
ERBB2 antibody	>9 publications with WWOX2 and ERBB2
MAPK8 antibody	>6 publications with WWOX2 and MAPK8
TNK2 antibody	>4 publications with WWOX2 and TNK2
YAP1 antibody	>3 publications with WWOX2 and YAP1
SRC antibody	>3 publications with WWOX2 and SRC
EZR antibody	>1 publications with WWOX2 and EZR

Diseases associated with anti-WWOX2 antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>101 publications with WWOX2 and Carcinoma
Breast Neoplasms Antibodies	>60 publications with WWOX2 and Breast Neoplasms
Lung Neoplasms Antibodies	>32 publications with WWOX2 and Lung Neoplasms
Chromosome Aberrations Antibodies	>29 publications with WWOX2 and Chromosome Aberrations
Nervous System Diseases Antibodies	>27 publications with WWOX2 and Nervous System Diseases
Ovarian Neoplasms Antibodies	>27 publications with WWOX2 and Ovarian Neoplasms
Neoplasms, Experimental Antibodies	>23 publications with WWOX2 and Neoplasms, Experimental
Neoplasm Metastasis Antibodies	>21 publications with WWOX2 and Neoplasm Metastasis
Cell Transformation, Neoplastic Antibodies	>19 publications with WWOX2 and Cell Transformation, Neoplastic
Liver Neoplasms Antibodies	>18 publications with WWOX2 and Liver Neoplasms

Organs/Tissues associated with anti-WWOX2 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>43 publications with WWOX2 and Lung
Prostate Antibodies	>32 publications with WWOX2 and Prostate
Brain Antibodies	>27 publications with WWOX2 and Brain
Bone Antibodies	>25 publications with WWOX2 and Bone
Liver Antibodies	>22 publications with WWOX2 and Liver
Blood Antibodies	>18 publications with WWOX2 and Blood
Lymph Antibodies	>12 publications with WWOX2 and Lymph
Kidney Antibodies	>8 publications with WWOX2 and Kidney
Ovary Antibodies	>8 publications with WWOX2 and Ovary
Nerve Antibodies	>6 publications with WWOX2 and Nerve