• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Sodium / Hydrogen (SLC9A3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS540410

Affinity Purified Sodium/Hydrogen Exchanger 3 isoform 1 AntibodyInvolved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical… More details

$480 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Sodium / Hydrogen (SLC9A3), Polyclonal Antibody
Full Product Name
Sodium / Hydrogen Exchanger 3 Antibody Affinity Purified
Product Gene Name
anti-SLC9A3 antibody
Product Synonym Names
MGC126718; MGC126720; NHE3; SLC9A 3; Sodium/hydrogen exchanger 3; Solute carrier family 9 member 3 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Monkey, Mouse, Rat
Form/Format
Affinity Purified
Concentration
0.68 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: Sodium / Hydrogen (MBS540410)
Positive Control: Sodium / Hydrogen (MBS543268)
Antibody/Peptide Pairs
Sodium / Hydrogen peptide (MBS544486) is used for blocking the activity of Sodium / Hydrogen antibody (MBS540410)
Molecular Weight
91,904 Da
OMIM
182307
3D Structure
ModBase 3D Structure for P48764
Immunogen
Synthetic peptide taken within amino acid region 790-835 on Slc9A3 protein.
Molecular Function
PDZ domain binding; Sodium:proton antiporter activity
Structure
Binds SLC9A3R1 and SLC9A3R2. Interacts with CHP1, CHP2 and SHANK2. Interacts with PDZK1 (via C-terminal PDZ domain) (By similarity). Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels.
Subcellular Location
Apical cell membrane; Multi-pass membrane protein

Product Categories/Family for anti-SLC9A3 antibody

Primary Antibodies; Channels & Transporters; Sodium/Hydrogen Exchanger 3 Antibody
Applications Tested/Suitable for anti-SLC9A3 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-SLC9A3 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500

Western Blot (WB) of anti-SLC9A3 antibody

Rabbit Anti-SLC9A3 Polyclonal Antibody – Cat# MBS540410

Other Notes

Small volumes of anti-SLC9A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC9A3 purchase

MBS540410 is an antibody targeting SLC9A3. Also known as Sodium / Hydrogen Exchanger 3 Antibody Affinity Purified. Reactive in Human, Monkey, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC9A3. It may not necessarily be applicable to this product.

NCBI GI #
194239733
NCBI GeneID
6550
NCBI Accession #
NP_004165.2
UniProt Primary Accession #
P48764
UniProt Secondary Accession #
Q3MIW3; B7ZKR2; E9PF67
UniProt Related Accession #
P48764
GenBank Nucleotide #
NM_004174.3
NCBI Official Full Name
sodium/hydrogen exchanger 3 isoform 1
NCBI Official Synonym Full Names
solute carrier family 9 member A3
NCBI Official Symbol
SLC9A3
NCBI Official Synonym Symbols
NHE3; DIAR8; NHE-3
UniProt Protein Name
Sodium/hydrogen exchanger 3
UniProt Synonym Protein Names
Na(+)/H(+) exchanger 3
Protein Family
Sodium/hydrogen exchanger
UniProt Gene Name
SLC9A3
UniProt Synonym Gene Names
NHE-3
UniProt Entry Name
SL9A3_HUMAN
NCBI Protein Information
sodium/hydrogen exchanger 3

NCBI Summary for SLC9A3

The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016]
Show more

UniProt Comments for SLC9A3

NHE3: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Binds SLC9A3R1 and SLC9A3R2. Interacts with SHANK2. Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

Protein type: Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5p15.3

Cellular Component: apical plasma membrane; brush border; brush border membrane; cell surface; integral to membrane; plasma membrane

Molecular Function: PDZ domain binding; protein binding; sodium:hydrogen antiporter activity

Biological Process: circadian rhythm; ion transport; receptor-mediated endocytosis; regulation of pH; regulation of sodium ion transport; response to glucocorticoid stimulus
Show more

Research Articles on SLC9A3

1. Inflammation-induced loss of PDZK1 expression may contribute to the NHE3 dysfunction observed in the inflamed intestine.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SLC9A3 antibody

 Products by Pathway  Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Proximal Tubule Bicarbonate Reclamation Pathway antibodies  Proximal Tubule Bicarbonate Reclamation Pathway Diagram
 Proximal Tubule Bicarbonate Reclamation Pathway antibodies  Proximal Tubule Bicarbonate Reclamation Pathway Diagram
 RhoA Signaling Pathway antibodies  RhoA Signaling Pathway Diagram

Diseases associated with anti-SLC9A3 antibody

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >8 publications with SLC9A3 and Fibrosis
 Inflammation Antibodies  >5 publications with SLC9A3 and Inflammation
 Diarrhea Antibodies  >5 publications with SLC9A3 and Diarrhea
 Hypertension Antibodies  >4 publications with SLC9A3 and Hypertension
 CYSTIC FIBROSIS, MODIFIER OF, 1 Antibodies  >3 publications with SLC9A3 and CYSTIC FIBROSIS, MODIFIER OF, 1
 Kidney Diseases Antibodies  >2 publications with SLC9A3 and Kidney Diseases
 Intestinal Obstruction Antibodies  >2 publications with SLC9A3 and Intestinal Obstruction
 Infertility, Male Antibodies  >2 publications with SLC9A3 and Infertility, Male
 Heart Failure Antibodies  >1 publications with SLC9A3 and Heart Failure
 Cardiovascular Abnormalities Antibodies  >1 publications with SLC9A3 and Cardiovascular Abnormalities

Organs/Tissues associated with anti-SLC9A3 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >11 publications with SLC9A3 and Intestine
 Lung Antibodies  >7 publications with SLC9A3 and Lung
 Embryonic Tissue Antibodies  >3 publications with SLC9A3 and Embryonic Tissue
 Skin Antibodies  >2 publications with SLC9A3 and Skin
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000