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EXODUS-2 Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553153

Exodus-2, which is a member of the family of CC- Chemokines, has a unique 36 (murine) or 37 (human) amino acid carboxyl-terminal extension not seen in other chemokines. Exodus-2 selectively stimulates the chemotaxis of adult T-lymphocytes and is expressed… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Exodus-2, Recombinant Protein
Full Product Name
Mouse Exodus-2 Recombinant
Product Gene Name
Exodus-2 recombinant protein
Product Synonym Names
Exodus-2; Exodus2; ccl21
Sequence
MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK QEPSLGCPIP AILFSPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS PGCRKNRGTS KSGKKGKGSK GCKRTEQTQP SRG
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant mouse Exodus-2 was lyophilized from a 0.2 um filtered PBS solution.
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Molecular Weight
14,558 Da
3D Structure
ModBase 3D Structure for P84444
Domain
IL8
Host Note
Optimized DNA sequence encoding Mouse Exodus-2 mature chain was expressed in Escherichia Coli.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Molecular Weight Note
Native mouse Exodus-2 is generated by the proteolytic removal of the signal peptide
and propeptide, this molecule has a calculated molecular mass of approximately 12 kDa.

Recombinant mouse Exodus-2 is a disulfide-linked homodimeric protein consisting of 111 amino acid residue subunits, and migrates as an approximately 12 kDa protein under non-reducing and reducing conditions in SDS-PAGE.

Product Categories/Family for Exodus-2 recombinant protein

Cytokines

Other Notes

Small volumes of Exodus-2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Exodus-2 purchase

MBS553153 is a recombinant protein targeting Exodus-2. Also known as Mouse Exodus-2 Recombinant. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for Exodus-2. It may not necessarily be applicable to this product.

NCBI GI #
302488378
NCBI GeneID
100504362
NCBI Accession #
NP_001180596.1
UniProt Primary Accession #
P84444
UniProt Secondary Accession #
O09002; O09006; Q3U1J2; Q91V84
UniProt Related Accession #
P84444
GenBank Nucleotide #
NM_001193667.1
NCBI Official Full Name
predicted gene 1987
UniProt Protein Name
C-C motif chemokine 21a
UniProt Synonym Protein Names
6Ckine; Beta-chemokine exodus-2; Small-inducible cytokine A21a; Thymus-derived chemotactic agent 4
Protein Family
C-C motif chemokine
UniProt Gene Name
Ccl21a
UniProt Synonym Gene Names
Scya21; Scya21a; TCA4
UniProt Entry Name
CC21A_MOUSE

UniProt Comments for Exodus-2

CCL21a: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T- cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Mice carrying an autosomal recessive mutation designated paucity of lymph node T-cells (plt) show dramatically reduced numbers of T-cells in lymph nodes, Peyer patches, and the white pulp of the spleen. Plt seems to correspond to Scya21b. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine

Molecular Function: chemokine activity; chemokine receptor binding

Biological Process: lymph node development; induction of positive chemotaxis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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