Tozadenant Inhibitor

Name: Tozadenant Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5752465
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752465

Tozadenant is an adenosine A2A receptor antagonist (Ki of 11.5nM and 6nM on human and rhesus,respectively) More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tozadenant, Inhibitor

Full Product Name

Tozadenant

Product Synonym Names

SYN115

Form/Format

Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Molecular Weight

406.5

Formula

C19H26N4O4S

CAS

870070-55-6

Smiles

COc1ccc(N2CCOCC2)c2sc(NC(=O)N3CCC(C)(O)CC3)nc12

Receptor (IC50)

adenosine A2A receptor (human): 11.5nM (Ki)
adenosine A2A receptor (rhesus): 6nM (Ki)

Solubility

DMSO: 50mg/mL (123.00mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Product Categories/Family for Tozadenant, inhibitor

Home; GPCR/G Protein; Adenosine Receptor

Product References and Citations for Tozadenant, inhibitor

1. Anne M, Jean-Marie N, Sarah R, et al. Antiparkinsonian effects of the "Radiprodil and Tozadenant" combination in MPTP-treated marmosets[J]. PLOS ONE 2017 12 (8):e0182887-.
2. Hauser R A, Olanow C W, Kieburtz K D, et al. Tozadenant (SYN115) in patients with Parkinson's disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial[J]. The Lancet Neurology, 2014, 13 (8):767-776.
3. Barret O, Hannestad J, Alagille D, et al. Adenosine 2A Receptor Occupancy by Tozadenant and Preladenant in Rhesus Monkeys[J]. Journal of Nuclear Medicine, 2014, 55 (10):1712-1718.

Other Notes

Small volumes of Tozadenant, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tozadenant purchase

MBS5752465 is an inhibitor targeting Tozadenant.