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Linaprazan Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5752753

Linaprazan inhibits gastric H+, K+-ATPase by K+-competitive binding (IC50: 1.0uM). It is an acid-suppressing compound with a rapid onset of action and potent acid inhibition. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Linaprazan, Inhibitor
Full Product Name
Linaprazan
Product Synonym Names
AZD0865
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
366.46
Solubility
DMSO: 35mg/mL (95.51mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C21H26N4O2
SMILES
O=C(C1=CN2C(C(NCC3=C(C)C=CC=C3C)=C1)=NC(C)=C2C)NCCO
CAS Number
248919-64-4
Target & IC50
Others
In Vitro
The reference for animal administration is 0.5-1.0mg/kg. The greater degree of acid suppression with the 75-mg dose of Linaprazan would translate to a healing rate of 89% at 4 weeks [2].

Product References and Citations for Linaprazan, inhibitor

Gedda K et al. Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+,K+-ATPase. Biochem Pharmacol. 2007 Jan 15;73(2):198-205.
Gedda K et al. Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+,K+-ATPase. Biochem Pharmacol. 2007 Jan 15;73(2):198-205.
Kahrilas PJ et al. A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitis. Clin Gastroenterol Hepatol. 2007 Dec;5(12):1385-91.
Kahrilas PJ et al. A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitis. Clin Gastroenterol Hepatol. 2007 Dec;5(12):1385-91.

Other Notes

Small volumes of Linaprazan, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Linaprazan purchase

MBS5752753 is an inhibitor targeting Linaprazan.
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