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VU0467154 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755704

VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor. The response to ACh with pEC50s of 7.75, 6.2, and 6 for a rat, human, and cynomolgus monkey M4 receptor, respectively. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
VU0467154, Inhibitor
Full Product Name
VU0467154
Product Gene Name
VU0467154, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
444.45
Solubility
DMSO: 125mg/mL (281.25mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C17H15F3N4O3S2
SMILES
O=C(C1=C(N)C2=C(C)C(C)=NN=C2S1)NCC3=CC=C(S(=O)(C(F)(F)F)=O)C=C3
CAS Number
1451993-15-9
Target & IC50
Rat M4 receptor: ic50 7.75 (pEC50)
Human M4 receptor: ic50 6.2 (pEC50)
Cynomolgus monkey M4 receptor: ic50 6 (pEC50)

Structure of VU0467154, inhibitor

VU0467154 Inhibitor – Cat# MBS5755704

Product References and Citations for VU0467154, inhibitor

1. Bubser M, et al. Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents. ACS Chem Neurosci. 2014 Oct 15;5(10):920-42.

Other Notes

Small volumes of VU0467154, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VU0467154 purchase

MBS5755704 is an inhibitor targeting VU0467154.
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