Masitinib mesylate Inhibitor

Masitinib mesylate is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200nM,540/800nM,510nM for human recombinant c-Kit;PDGFRalpha/beta;LynB, respectively).

Dubreuil P, et al. Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT. PLoS One, 2009, 4(9), e7258.
Dubreuil P, et al. Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT. PLoS One, 2009, 4(9), e7258.
Hahn KA, et al. Masitinib is safe and effective for the treatment,of canine mast cell tumors. J Vet Intern Med, 2008, 22(6), 1301-1309.
Hahn KA, et al. Masitinib is safe and effective for the treatment,of canine mast cell tumors. J Vet Intern Med, 2008, 22(6), 1301-1309.
Marech I, et al. Masitinib (AB1010), from canine tumor model to human clinical development: where we are, Crit Rev Oncol Hematol. 2014 Jul;91(1):98-111.
Marech I, et al. Masitinib (AB1010), from canine tumor model to human clinical development: where we are, Crit Rev Oncol Hematol. 2014 Jul;91(1):98-111.

Small volumes of Masitinib mesylate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5759331 is an inhibitor targeting Masitinib mesylate.