Mouse Anti-ATG16L1 Monoclonal Antibody – Cat# MBS6220560

ATG16L1 Antibody – Mouse Monoclonal

Name: ATG16L1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6220560
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6220560

The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to… More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ATG16L1, Monoclonal Antibody

Full Product Name

ATG16L1 (Autophagy-related protein 16-1, APG16-like 1, ATG16L1, APG16L) (MaxLight 650)

Product Gene Name

anti-ATG16L1 antibody

Product Synonym Names

Autophagy-related protein 16-1; APG16-like 1; ATG16L1; APG16L

Clonality

Monoclonal

Isotype

IgG1,k

Clone Number

54CT27.2.6

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

Purity/Purification

Purified by Protein G Affinity Chromatography

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

68,265 Da

Chromosome Location

Chromosome: 2; NC_000002.11 (234160217..234204320). Location: 2q37.1

OMIM

610767

3D Structure

ModBase 3D Structure for Q676U5

Immunogen

Purified His-tagged ATG16L1 protein (fragment).

Conjugate

MaxLight650

Product Categories/Family for anti-ATG16L1 antibody

Antibodies; Autophagy

Applications Tested/Suitable for anti-ATG16L1 antibody

FLISA, Immunohistochemistry (IHC), Western Blot (WB)

Application Notes for anti-ATG16L1 antibody

FLISA: 1:4000
IHC: 1:10-50
WB: 1:60
Applications are based on unconjugated antibody.

Product References and Citations for anti-ATG16L1 antibody

Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. Metzger S, et al. Hum Genet, 2010 Oct. PMID 20697744. Plasma membrane contributes to the formation of pre-autophagosomal structures. Ravikumar B, et al. Nat Cell Biol, 2010 Aug. PMID 20639872. Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's disease. Cotterill L, et al. Can J Gastroenterol, 2010 May. PMID 20485703. Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas? Wolfkamp SC, et al. Eur J Gastroenterol Hepatol, 2010 Aug. PMID 20395867. NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease. Gazouli M, et al. World J Gastroenterol, 2010 Apr 14. PMID 20380008.

Other Notes

Small volumes of anti-ATG16L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ATG16L1 purchase

MBS6220560 is an antibody targeting ATG16L1. Also known as ATG16L1 (Autophagy-related protein 16-1, APG16-like 1, ATG16L1, APG16L) (MaxLight 650). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ATG16L1. It may not necessarily be applicable to this product.

NCBI GI #

298229005

NCBI GeneID

55054

NCBI Accession #

NP_001177195.1

UniProt Primary Accession #

Q676U5

UniProt Secondary Accession #

Q6IPN1; Q6UXW4; Q6ZVZ5; Q8NCY2; Q96JV5; Q9H619; A3EXK9; A3EXL0; B6ZDH0

UniProt Related Accession #

Q676U5

GenBank Nucleotide #

NM_001190266.1

NCBI Official Full Name

autophagy-related protein 16-1 isoform 4

NCBI Official Synonym Full Names

autophagy related 16-like 1 (S. cerevisiae)

NCBI Official Symbol

ATG16L1

NCBI Official Synonym Symbols

IBD10; WDR30; APG16L; ATG16A; ATG16L

UniProt Protein Name

Autophagy-related protein 16-1

UniProt Synonym Protein Names

APG16-like 1

Protein Family

Autophagy-related protein

UniProt Gene Name

ATG16L1

UniProt Synonym Gene Names

APG16L

UniProt Entry Name

A16L1_HUMAN

NCBI Protein Information

autophagy-related protein 16-1; APG16L beta; WD repeat domain 30; ATG16 autophagy related 16-like 1

UniProt Comments for ATG16L1

ATG16: Plays an essential role in autophagy. Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Belongs to the WD repeat ATG16 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, peripheral; Adaptor/scaffold; Autophagy

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: pre-autophagosomal structure membrane; autophagic vacuole; axoneme

Molecular Function: identical protein binding; protein binding

Biological Process: protein transport; protein homooligomerization; autophagic vacuole formation

Disease: Inflammatory Bowel Disease 10

Research Articles on ATG16L1

1. TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ATG16L1 antibody

Reference Product	PubMed Publications
ATG5 antibody	>26 publications with ATG16L1 and ATG5

Pathways associated with anti-ATG16L1 antibody

Products by Pathway	Pathway Diagram
Senescence And Autophagy Pathway antibodies	Senescence And Autophagy Pathway Diagram

Diseases associated with anti-ATG16L1 antibody

Disease Name	Pubmed Publications
Crohn Disease Antibodies	>130 publications with ATG16L1 and Crohn Disease
Inflammation Antibodies	>46 publications with ATG16L1 and Inflammation
Inflammatory Bowel Disease 10 Antibodies	>36 publications with ATG16L1 and Inflammatory Bowel Disease 10
Necrosis Antibodies	>16 publications with ATG16L1 and Necrosis
Neoplasms Antibodies	>6 publications with ATG16L1 and Neoplasms
Disease Models, Animal Antibodies	>6 publications with ATG16L1 and Disease Models, Animal
Death Antibodies	>3 publications with ATG16L1 and Death
Liver Diseases Antibodies	>3 publications with ATG16L1 and Liver Diseases
Carcinoma Antibodies	>3 publications with ATG16L1 and Carcinoma
Nervous System Diseases Antibodies	>3 publications with ATG16L1 and Nervous System Diseases

Organs/Tissues associated with anti-ATG16L1 antibody

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>35 publications with ATG16L1 and Intestine
Blood Antibodies	>21 publications with ATG16L1 and Blood
Brain Antibodies	>6 publications with ATG16L1 and Brain
Liver Antibodies	>4 publications with ATG16L1 and Liver
Nerve Antibodies	>4 publications with ATG16L1 and Nerve
Bone Marrow Antibodies	>3 publications with ATG16L1 and Bone Marrow
Bone Antibodies	>3 publications with ATG16L1 and Bone
Heart Antibodies	>3 publications with ATG16L1 and Heart
Muscle Antibodies	>1 publications with ATG16L1 and Muscle
Thymus Antibodies	>1 publications with ATG16L1 and Thymus